node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IKBKG | MAP2K6 | ENSSSCP00000048392 | ENSSSCP00000018281 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | 0.524 |
IKBKG | MAP3K7 | ENSSSCP00000048392 | ENSSSCP00000057259 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.997 |
IKBKG | RIPK2 | ENSSSCP00000048392 | ENSSSCP00000028599 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.862 |
IKBKG | TAB1 | ENSSSCP00000048392 | ENSSSCP00000028647 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.997 |
IKBKG | TAB2 | ENSSSCP00000048392 | ENSSSCP00000036269 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. | 0.998 |
IKBKG | TAB3 | ENSSSCP00000048392 | ENSSSCP00000060766 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. | 0.997 |
MAP2K6 | IKBKG | ENSSSCP00000018281 | ENSSSCP00000048392 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | 0.524 |
MAP2K6 | MAP3K7 | ENSSSCP00000018281 | ENSSSCP00000057259 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.964 |
MAP2K6 | MAPK11 | ENSSSCP00000018281 | ENSSSCP00000031859 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.984 |
MAP2K6 | MAPK12 | ENSSSCP00000018281 | ENSSSCP00000052624 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.972 |
MAP2K6 | MAPK13 | ENSSSCP00000018281 | ENSSSCP00000072044 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.968 |
MAP2K6 | MAPK14 | ENSSSCP00000018281 | ENSSSCP00000064942 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.997 |
MAP2K6 | RIPK2 | ENSSSCP00000018281 | ENSSSCP00000028599 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.581 |
MAP2K6 | TAB1 | ENSSSCP00000018281 | ENSSSCP00000028647 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.915 |
MAP2K6 | TAB2 | ENSSSCP00000018281 | ENSSSCP00000036269 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. | 0.908 |
MAP2K6 | TAB3 | ENSSSCP00000018281 | ENSSSCP00000060766 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. | 0.908 |
MAP3K7 | IKBKG | ENSSSCP00000057259 | ENSSSCP00000048392 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | 0.997 |
MAP3K7 | MAP2K6 | ENSSSCP00000057259 | ENSSSCP00000018281 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | 0.964 |
MAP3K7 | MAPK11 | ENSSSCP00000057259 | ENSSSCP00000031859 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Mitogen-activated protein kinase. | 0.580 |
MAP3K7 | MAPK12 | ENSSSCP00000057259 | ENSSSCP00000052624 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.918 |