(14 nodes) GAB1 signalosome network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PXN	Uncharacterized protein. (1072 aa)
	CSK	Tyrosine-protein kinase. (474 aa)
	AREG	Amphiregulin long form. (247 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	GAB1	GRB2 associated binding protein 1. (723 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	BTC	EGF-like domain-containing protein. (342 aa)
	PAG1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (435 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	HBEGF	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	EREG	Epiregulin. (168 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSSSCP00000009565	ENSSSCP00000036969	Amphiregulin long form.	EGF-like domain-containing protein.	0.949
AREG	CSK	ENSSSCP00000009565	ENSSSCP00000002078	Amphiregulin long form.	Tyrosine-protein kinase.	0.535
AREG	EGFR	ENSSSCP00000009565	ENSSSCP00000068369	Amphiregulin long form.	Receptor protein-tyrosine kinase.	0.997
AREG	EREG	ENSSSCP00000009565	ENSSSCP00000067883	Amphiregulin long form.	Epiregulin.	0.974
AREG	GAB1	ENSSSCP00000009565	ENSSSCP00000029177	Amphiregulin long form.	GRB2 associated binding protein 1.	0.499
AREG	GRB2	ENSSSCP00000009565	ENSSSCP00000018229	Amphiregulin long form.	Growth factor receptor-bound protein 2 isoform 1.	0.522
AREG	HBEGF	ENSSSCP00000009565	ENSSSCP00000060087	Amphiregulin long form.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.725
AREG	PAG1	ENSSSCP00000009565	ENSSSCP00000048300	Amphiregulin long form.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.499
AREG	PIK3CA	ENSSSCP00000009565	ENSSSCP00000052984	Amphiregulin long form.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.561
AREG	PIK3R1	ENSSSCP00000009565	ENSSSCP00000024885	Amphiregulin long form.	Phosphoinositide-3-kinase regulatory subunit 1.	0.499
AREG	PTPN11	ENSSSCP00000009565	ENSSSCP00000064345	Amphiregulin long form.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.499
AREG	PXN	ENSSSCP00000009565	ENSSSCP00000064760	Amphiregulin long form.	Uncharacterized protein.	0.515
AREG	SRC	ENSSSCP00000009565	ENSSSCP00000029882	Amphiregulin long form.	Tyrosine-protein kinase.	0.675
BTC	AREG	ENSSSCP00000036969	ENSSSCP00000009565	EGF-like domain-containing protein.	Amphiregulin long form.	0.949
BTC	CSK	ENSSSCP00000036969	ENSSSCP00000002078	EGF-like domain-containing protein.	Tyrosine-protein kinase.	0.499
BTC	EGFR	ENSSSCP00000036969	ENSSSCP00000068369	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.983
BTC	EREG	ENSSSCP00000036969	ENSSSCP00000067883	EGF-like domain-containing protein.	Epiregulin.	0.835
BTC	GAB1	ENSSSCP00000036969	ENSSSCP00000029177	EGF-like domain-containing protein.	GRB2 associated binding protein 1.	0.499
BTC	GRB2	ENSSSCP00000036969	ENSSSCP00000018229	EGF-like domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.489
BTC	HBEGF	ENSSSCP00000036969	ENSSSCP00000060087	EGF-like domain-containing protein.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.834