(16 nodes) Norepinephrine Neurotransmitter Release Cycle network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (295 aa)
	RAB3A	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
	PPFIA4	PTPRF interacting protein alpha 4. (1210 aa)
	SLC18A2	MFS domain-containing protein. (517 aa)
	PPFIA2	PTPRF interacting protein alpha 2. (1286 aa)
	SYT1	Synaptotagmin 1. (379 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1235 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
	PPFIA1	PTPRF interacting protein alpha 1. (1231 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1684 aa)
	TSPOAP1	TSPO associated protein 1. (1855 aa)
	CPLX1	Complexin 1. (133 aa)
	UNC13B	Uncharacterized protein. (4266 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (189 aa)
	SLC22A2	Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] (554 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPLX1	PPFIA1	ENSSSCP00000066838	ENSSSCP00000050869	Complexin 1.	PTPRF interacting protein alpha 1.	0.520
CPLX1	PPFIA2	ENSSSCP00000066838	ENSSSCP00000031552	Complexin 1.	PTPRF interacting protein alpha 2.	0.592
CPLX1	PPFIA3	ENSSSCP00000066838	ENSSSCP00000032639	Complexin 1.	PTPRF interacting protein alpha 3.	0.544
CPLX1	PPFIA4	ENSSSCP00000066838	ENSSSCP00000016406	Complexin 1.	PTPRF interacting protein alpha 4.	0.520
CPLX1	RAB3A	ENSSSCP00000066838	ENSSSCP00000014777	Complexin 1.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.566
CPLX1	RIMS1	ENSSSCP00000066838	ENSSSCP00000062116	Complexin 1.	Regulating synaptic membrane exocytosis 1.	0.810
CPLX1	SLC18A2	ENSSSCP00000066838	ENSSSCP00000019413	Complexin 1.	MFS domain-containing protein.	0.582
CPLX1	SNAP25	ENSSSCP00000066838	ENSSSCP00000053403	Complexin 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.984
CPLX1	STX1A	ENSSSCP00000066838	ENSSSCP00000008300	Complexin 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.957
CPLX1	STXBP1	ENSSSCP00000066838	ENSSSCP00000037046	Complexin 1.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.836
CPLX1	SYT1	ENSSSCP00000066838	ENSSSCP00000001015	Complexin 1.	Synaptotagmin 1.	0.877
CPLX1	TSPOAP1	ENSSSCP00000066838	ENSSSCP00000064427	Complexin 1.	TSPO associated protein 1.	0.506
CPLX1	UNC13B	ENSSSCP00000066838	ENSSSCP00000067794	Complexin 1.	Uncharacterized protein.	0.578
CPLX1	VAMP2	ENSSSCP00000066838	ENSSSCP00000071291	Complexin 1.	V-SNARE coiled-coil homology domain-containing protein.	0.934
PPFIA1	CPLX1	ENSSSCP00000050869	ENSSSCP00000066838	PTPRF interacting protein alpha 1.	Complexin 1.	0.520
PPFIA1	PPFIA2	ENSSSCP00000050869	ENSSSCP00000031552	PTPRF interacting protein alpha 1.	PTPRF interacting protein alpha 2.	0.409
PPFIA1	PPFIA3	ENSSSCP00000050869	ENSSSCP00000032639	PTPRF interacting protein alpha 1.	PTPRF interacting protein alpha 3.	0.426
PPFIA1	PPFIA4	ENSSSCP00000050869	ENSSSCP00000016406	PTPRF interacting protein alpha 1.	PTPRF interacting protein alpha 4.	0.409
PPFIA1	RAB3A	ENSSSCP00000050869	ENSSSCP00000014777	PTPRF interacting protein alpha 1.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.605
PPFIA1	RIMS1	ENSSSCP00000050869	ENSSSCP00000062116	PTPRF interacting protein alpha 1.	Regulating synaptic membrane exocytosis 1.	0.632