STRINGSTRING
HGS HGS UBC UBC SPRY1 SPRY1 EREG EREG SH3GL2 SH3GL2 AREG AREG SH3KBP1 SH3KBP1 SH3GL1 SH3GL1 KXD1 KXD1 GRB2 GRB2 CDC42 CDC42 ARHGEF7 ARHGEF7 CBL CBL EPN1 EPN1 BTC BTC PTPRK PTPRK PTPN12 PTPN12 PTPN3 PTPN3 RPS27A RPS27A STAM2 STAM2 EPS15L1 EPS15L1 HBEGF HBEGF EPS15 EPS15 EGFR EGFR SH3GL3 SH3GL3 STAM STAM SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
EREGEpiregulin. (168 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
AREGAmphiregulin long form. (247 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (724 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (405 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
CBLCbl proto-oncogene. (914 aa)
EPN1Epsin 1. (576 aa)
BTCEGF-like domain-containing protein. (342 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1554 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (757 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (910 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
STAM2Signal transducing adaptor molecule 2. (517 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (944 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (979 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (512 aa)
STAMSignal transducing adaptor molecule. (521 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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