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HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa) | ||||
UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) | ||||
SPRY1 | Sprouty RTK signaling antagonist 1. (319 aa) | ||||
EREG | Epiregulin. (168 aa) | ||||
SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) | ||||
AREG | Amphiregulin long form. (247 aa) | ||||
SH3KBP1 | SH3 domain containing kinase binding protein 1. (724 aa) | ||||
SH3GL1 | SH3 domain containing GRB2 like 1, endophilin A2. (405 aa) | ||||
KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa) | ||||
GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) | ||||
CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa) | ||||
ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) | ||||
CBL | Cbl proto-oncogene. (914 aa) | ||||
EPN1 | Epsin 1. (576 aa) | ||||
BTC | EGF-like domain-containing protein. (342 aa) | ||||
PTPRK | Protein tyrosine phosphatase receptor type K. (1554 aa) | ||||
PTPN12 | Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (757 aa) | ||||
PTPN3 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (910 aa) | ||||
RPS27A | Ubiquitin-like domain-containing protein. (204 aa) | ||||
STAM2 | Signal transducing adaptor molecule 2. (517 aa) | ||||
EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (944 aa) | ||||
HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) | ||||
EPS15 | Epidermal growth factor receptor pathway substrate 15. (979 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1205 aa) | ||||
SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (512 aa) | ||||
STAM | Signal transducing adaptor molecule. (521 aa) | ||||
SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |