STRINGSTRING
PIK3R1 PIK3R1 RAPGEF1 RAPGEF1 PLCG1 PLCG1 PDGFA PDGFA SOS1 SOS1 CRKL CRKL PDGFRB PDGFRB GRB2 GRB2 STAT3 STAT3 GRB7 GRB7 STAT6 STAT6 KRAS KRAS NCK1 NCK1 SRC SRC CRK CRK PDGFB PDGFB NCK2 NCK2 NRAS NRAS PDGFRA PDGFRA BCAR1 BCAR1 HRAS HRAS PIK3CB PIK3CB PIK3CA PIK3CA RASA1 RASA1 PIK3R2 PIK3R2 PTPN11 PTPN11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1093 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
GRB7Growth factor receptor bound protein 7. (569 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NCK1Cytoplasmic protein. (377 aa)
SRCTyrosine-protein kinase. (559 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
NCK2Cytoplasmic protein. (376 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
PIK3R2Uncharacterized protein. (772 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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