STRINGSTRING
COL9A3 COL9A3 THBS1 THBS1 RAPGEF1 RAPGEF1 COL5A1 COL5A1 PLAT PLAT PLCG1 PLCG1 PDGFA PDGFA SOS1 SOS1 SPP1 SPP1 CRKL CRKL COL5A3 COL5A3 PDGFRB PDGFRB PDGFD PDGFD GRB2 GRB2 STAT3 STAT3 GRB7 GRB7 STAT6 STAT6 THBS4 THBS4 KRAS KRAS PDGFC PDGFC PIK3R1 PIK3R1 NCK1 NCK1 COL6A2 COL6A2 COL6A3 COL6A3 SRC SRC CRK CRK COL2A1 COL2A1 PDGFB PDGFB PTPN12 PTPN12 NCK2 NCK2 THBS3 THBS3 NRAS NRAS PDGFRA PDGFRA BCAR1 BCAR1 HRAS HRAS PIK3CB PIK3CB PIK3CA PIK3CA FURIN FURIN COL6A5 COL6A5 RASA1 RASA1 PIK3R2 PIK3R2 THBS2 THBS2 COL9A1 COL9A1 PTPN11 PTPN11 COL9A2 COL9A2 COL6A1 COL6A1 COL6A6 COL6A6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL9A3Collagen type IX alpha 3 chain. (684 aa)
THBS1Uncharacterized protein. (1170 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1093 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
COL5A3Collagen type V alpha 3 chain. (1747 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (387 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
GRB7Growth factor receptor bound protein 7. (569 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
THBS4Thrombospondin 4. (976 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
NCK1Cytoplasmic protein. (377 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
COL6A3Collagen type VI alpha 3 chain. (2911 aa)
SRCTyrosine-protein kinase. (559 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (757 aa)
NCK2Cytoplasmic protein. (376 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa)
COL6A5Collagen type VI alpha 5 chain. (2337 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
PIK3R2Uncharacterized protein. (772 aa)
THBS2Thrombospondin 2. (1223 aa)
COL9A1Collagen type IX alpha 1 chain. (922 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
COL9A2Uncharacterized protein. (709 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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