(49 nodes) NRAGE signals death through JNK network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RAC1	Rac family small GTPase 1. (186 aa)
	ARHGEF25	Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa)
	AKAP13	Uncharacterized protein. (1420 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1704 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	BCL2L11	Uncharacterized protein. (433 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	MAPK8	Mitogen-activated protein kinase. (411 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1611 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (960 aa)
	ARHGEF17	DH domain-containing protein. (1043 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3109 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (569 aa)
	FGD3	FYVE, RhoGEF and PH domain-containing protein 3 isoform X1. (735 aa)
	PLEKHG2	Pleckstrin homology and RhoGEF domain containing G2. (1357 aa)
	ARHGEF38	Rho guanine nucleotide exchange factor 38. (778 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (844 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1574 aa)
	ECT2	Epithelial cell transforming 2. (1028 aa)
	ARHGEF9	Uncharacterized protein. (1109 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1172 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	FGD2	FYVE, RhoGEF and PH domain containing 2. (656 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (711 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1270 aa)
	ARHGEF18	Rho guanine nucleotide exchange factor 18 isoform X3. (1346 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	BAD	BCL2 associated agonist of cell death. (209 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (1181 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (766 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (872 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (823 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19 isoform X1. (879 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1298 aa)
	NET1	Neuroepithelial cell transforming 1. (574 aa)
	FGD4	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1415 aa)
	ARHGEF33	Rho guanine nucleotide exchange factor 33. (868 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1274 aa)
	ABR	ABR activator of RhoGEF and GTPase. (964 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor 39. (370 aa)
	ITSN1	Intersectin 1. (1485 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (874 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1577 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (879 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	ARHGEF1	ENSSSCP00000059416	ENSSSCP00000044252	ABR activator of RhoGEF and GTPase.	Rho guanine nucleotide exchange factor 1.	0.426
ABR	GNA13	ENSSSCP00000059416	ENSSSCP00000040165	ABR activator of RhoGEF and GTPase.	G protein subunit alpha 13.	0.400
ABR	RAC1	ENSSSCP00000059416	ENSSSCP00000062132	ABR activator of RhoGEF and GTPase.	Rac family small GTPase 1.	0.543
ABR	TIAM1	ENSSSCP00000059416	ENSSSCP00000012816	ABR activator of RhoGEF and GTPase.	T cell lymphoma invasion and metastasis 1.	0.490
AKAP13	ARHGEF1	ENSSSCP00000002454	ENSSSCP00000044252	Uncharacterized protein.	Rho guanine nucleotide exchange factor 1.	0.449
AKAP13	ARHGEF11	ENSSSCP00000002454	ENSSSCP00000068410	Uncharacterized protein.	Rho guanine nucleotide exchange factor 11.	0.908
AKAP13	ARHGEF12	ENSSSCP00000002454	ENSSSCP00000047751	Uncharacterized protein.	Rho guanine nucleotide exchange factor 12.	0.915
AKAP13	ARHGEF16	ENSSSCP00000002454	ENSSSCP00000045630	Uncharacterized protein.	Rho guanine nucleotide exchange factor 16.	0.527
AKAP13	ECT2	ENSSSCP00000002454	ENSSSCP00000031646	Uncharacterized protein.	Epithelial cell transforming 2.	0.478
AKAP13	GNA13	ENSSSCP00000002454	ENSSSCP00000040165	Uncharacterized protein.	G protein subunit alpha 13.	0.927
AKAP13	RAC1	ENSSSCP00000002454	ENSSSCP00000062132	Uncharacterized protein.	Rac family small GTPase 1.	0.587
ARHGEF1	ABR	ENSSSCP00000044252	ENSSSCP00000059416	Rho guanine nucleotide exchange factor 1.	ABR activator of RhoGEF and GTPase.	0.426
ARHGEF1	AKAP13	ENSSSCP00000044252	ENSSSCP00000002454	Rho guanine nucleotide exchange factor 1.	Uncharacterized protein.	0.449
ARHGEF1	ARHGEF10L	ENSSSCP00000044252	ENSSSCP00000056096	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 10 like.	0.473
ARHGEF1	ARHGEF11	ENSSSCP00000044252	ENSSSCP00000068410	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 11.	0.473
ARHGEF1	ARHGEF12	ENSSSCP00000044252	ENSSSCP00000047751	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 12.	0.498
ARHGEF1	ARHGEF15	ENSSSCP00000044252	ENSSSCP00000025966	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 15.	0.442
ARHGEF1	ARHGEF16	ENSSSCP00000044252	ENSSSCP00000045630	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 16.	0.451
ARHGEF1	ARHGEF17	ENSSSCP00000044252	ENSSSCP00000015741	Rho guanine nucleotide exchange factor 1.	DH domain-containing protein.	0.465
ARHGEF1	ARHGEF18	ENSSSCP00000044252	ENSSSCP00000037677	Rho guanine nucleotide exchange factor 1.	Rho guanine nucleotide exchange factor 18 isoform X3.	0.479