STRINGSTRING
VAV3 VAV3 MAG MAG ARHGEF25 ARHGEF25 LINGO1 LINGO1 NFKBIA NFKBIA AKAP13 AKAP13 PSEN1 PSEN1 TIAM2 TIAM2 SOS2 SOS2 BCL2L11 BCL2L11 SOS1 SOS1 MAPK8 MAPK8 PRKCI PRKCI TIAM1 TIAM1 FGD1 FGD1 BEX3 BEX3 IRAK1 IRAK1 RELA RELA KXD1 KXD1 ARHGEF17 ARHGEF17 TRIO TRIO NGFR NGFR OMG OMG ARHGEF3 ARHGEF3 FGD3 FGD3 PLEKHG2 PLEKHG2 APH1B APH1B ARHGEF38 ARHGEF38 ARHGEF15 ARHGEF15 ARHGEF5 ARHGEF5 RIPK2 RIPK2 ECT2 ECT2 ARHGEF9 ARHGEF9 MCF2 MCF2 ARHGEF7 ARHGEF7 FGD2 FGD2 VAV1 VAV1 TRAF6 TRAF6 ARHGEF37 ARHGEF37 NCSTN NCSTN VAV2 VAV2 PREX1 PREX1 RASGRF2 RASGRF2 ARHGEF18 ARHGEF18 GNA13 GNA13 BAD BAD ARHGEF6 ARHGEF6 ARHGEF1 ARHGEF1 ARHGEF16 ARHGEF16 RHOA RHOA ARHGDIA ARHGDIA ARHGEF26 ARHGEF26 NGEF NGEF PSENEN PSENEN ARHGEF12 ARHGEF12 NFKB1 NFKB1 RPS27A RPS27A APH1A APH1A ARHGEF19 ARHGEF19 MCF2L MCF2L PSEN2 PSEN2 RTN4 RTN4 NET1 NET1 FGD4 FGD4 ARHGEF33 ARHGEF33 ARHGEF10L ARHGEF10L SQSTM1 SQSTM1 ABR ABR ARHGEF39 ARHGEF39 RAC1 RAC1 ARHGEF11 ARHGEF11 UBC UBC ITSN1 ITSN1 PLEKHG5 PLEKHG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
MAGMyelin associated glycoprotein. (625 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
AKAP13Uncharacterized protein. (1420 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1704 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
BCL2L11Uncharacterized protein. (433 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
MAPK8Mitogen-activated protein kinase. (411 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1611 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (960 aa)
BEX3Uncharacterized protein. (101 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (691 aa)
RELATranscription factor p65 isoform 1. (573 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
ARHGEF17DH domain-containing protein. (1043 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3109 aa)
NGFRNerve growth factor receptor. (414 aa)
OMGOligodendrocyte-myelin glycoprotein. (443 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (569 aa)
FGD3FYVE, RhoGEF and PH domain-containing protein 3 isoform X1. (735 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1357 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (264 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (778 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (844 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
ECT2Epithelial cell transforming 2. (1028 aa)
ARHGEF9Uncharacterized protein. (1109 aa)
MCF2MCF.2 cell line derived transforming sequence. (1172 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (656 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (711 aa)
NCSTNNicastrin isoform 1. (709 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1270 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X3. (1346 aa)
GNA13G protein subunit alpha 13. (377 aa)
BADBCL2 associated agonist of cell death. (209 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1181 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (766 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (270 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (872 aa)
NGEFNeuronal guanine nucleotide exchange factor. (823 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
NFKB1Uncharacterized protein. (898 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19 isoform X1. (879 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1298 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (485 aa)
RTN4Reticulon. (1199 aa)
NET1Neuroepithelial cell transforming 1. (574 aa)
FGD4Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1415 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (868 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1274 aa)
SQSTM1Sequestosome 1. (451 aa)
ABRABR activator of RhoGEF and GTPase. (964 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (370 aa)
RAC1Rac family small GTPase 1. (186 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1577 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
ITSN1Intersectin 1. (1485 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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