STRINGSTRING
WASF3 WASF3 PTK2B PTK2B ABI1 ABI1 BRK1 BRK1 PAK2 PAK2 VEGFD VEGFD CTNND1 CTNND1 FLT4 FLT4 CTNNA1 CTNNA1 MAPKAPK2 MAPKAPK2 VEGFC VEGFC SPHK1 SPHK1 PRKCA PRKCA JUP JUP KRAS KRAS WASF2 WASF2 PIK3R1 PIK3R1 NCK1 NCK1 ELMO2 ELMO2 PRKCZ PRKCZ KDR KDR CDC42 CDC42 SRC SRC PAK1 PAK1 ITGAV ITGAV CTNNB1 CTNNB1 MAPK11 MAPK11 SH2D2A SH2D2A VAV1 VAV1 CRK CRK ACTB ACTB PDPK1 PDPK1 NCF2 NCF2 ABI2 ABI2 DOCK1 DOCK1 MAPKAPK3 MAPKAPK3 AXL AXL ACTG1 ACTG1 NCK2 NCK2 NCKAP1 NCKAP1 RHOA RHOA WASF1 WASF1 HSP90AA1 HSP90AA1 NRAS NRAS CYFIP2 CYFIP2 BCAR1 BCAR1 NRP2 NRP2 HRAS HRAS MAPK12 MAPK12 PIK3CB PIK3CB PIK3CA PIK3CA PRKCD PRKCD BAIAP2 BAIAP2 SHC2 SHC2 ROCK2 ROCK2 RASA1 RASA1 PIK3R2 PIK3R2 RAC1 RAC1 FLT1 FLT1 ROCK1 ROCK1 PXN PXN MAPK14 MAPK14 NCKAP1L NCKAP1L VAV3 VAV3 NRP1 NRP1 VAV2 VAV2 MAPK13 MAPK13 NCF4 NCF4 ITGB3 ITGB3 FYN FYN SHB SHB PLCG1 PLCG1 NCF1 NCF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WASF3Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ABI1Abl interactor 1 isoform b. (481 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (103 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
VEGFDVascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CTNND1Catenin delta 1. (940 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
CTNNA1Catenin alpha 1. (1090 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
JUPJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
NCK1Cytoplasmic protein. (377 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
SRCTyrosine-protein kinase. (559 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
CTNNB1Catenin beta 1. (808 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SH2D2ASH2 domain containing 2A. (520 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
NCF2Neutrophil cytosolic factor 2. (643 aa)
ABI2Abl interactor 2. (542 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
MAPKAPK3Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
AXLUncharacterized protein. (871 aa)
ACTG1Actin gamma 1. (381 aa)
NCK2Cytoplasmic protein. (376 aa)
NCKAP1NCK associated protein 1. (1134 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
WASF1WH2 domain-containing protein. (559 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (920 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK12Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (386 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
BAIAP2BAI1 associated protein 2. (575 aa)
SHC2Uncharacterized protein. (623 aa)
ROCK2Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
PIK3R2Uncharacterized protein. (772 aa)
RAC1Rac family small GTPase 1. (186 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PXNUncharacterized protein. (1072 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
NCF4Neutrophil cytosolic factor 4. (381 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
SHBSH2 domain-containing protein. (507 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
NCF1Uncharacterized protein. (378 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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