(14 nodes) Beta-catenin phosphorylation cascade network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PPP2CB	Serine/threonine-protein phosphatase. (476 aa)
	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
	PPP2CA	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
	AMER1	APC membrane recruitment protein 1. (1108 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	APC	APC_basic domain-containing protein. (2713 aa)
	FRAT1	Uncharacterized protein. (279 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (477 aa)
	FRAT2	FRAT regulator of WNT signaling pathway 2. (228 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (614 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (659 aa)
	AXIN1	Axin 1. (867 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	APC	ENSSSCP00000029629	ENSSSCP00000037698	APC membrane recruitment protein 1.	APC_basic domain-containing protein.	0.971
AMER1	AXIN1	ENSSSCP00000029629	ENSSSCP00000072335	APC membrane recruitment protein 1.	Axin 1.	0.946
AMER1	CTNNB1	ENSSSCP00000029629	ENSSSCP00000031836	APC membrane recruitment protein 1.	Catenin beta 1.	0.932
AMER1	FRAT1	ENSSSCP00000029629	ENSSSCP00000038733	APC membrane recruitment protein 1.	Uncharacterized protein.	0.400
AMER1	FRAT2	ENSSSCP00000029629	ENSSSCP00000053206	APC membrane recruitment protein 1.	FRAT regulator of WNT signaling pathway 2.	0.400
AMER1	GSK3B	ENSSSCP00000029629	ENSSSCP00000046229	APC membrane recruitment protein 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.850
AMER1	PPP2CA	ENSSSCP00000029629	ENSSSCP00000015208	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	0.522
AMER1	PPP2CB	ENSSSCP00000029629	ENSSSCP00000072937	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase.	0.508
AMER1	PPP2R5A	ENSSSCP00000029629	ENSSSCP00000016538	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.499
AMER1	PPP2R5B	ENSSSCP00000029629	ENSSSCP00000013841	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.499
AMER1	PPP2R5C	ENSSSCP00000029629	ENSSSCP00000068274	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.499
AMER1	PPP2R5D	ENSSSCP00000029629	ENSSSCP00000055382	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.499
AMER1	PPP2R5E	ENSSSCP00000029629	ENSSSCP00000050867	APC membrane recruitment protein 1.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.499
APC	AMER1	ENSSSCP00000037698	ENSSSCP00000029629	APC_basic domain-containing protein.	APC membrane recruitment protein 1.	0.971
APC	AXIN1	ENSSSCP00000037698	ENSSSCP00000072335	APC_basic domain-containing protein.	Axin 1.	0.996
APC	CTNNB1	ENSSSCP00000037698	ENSSSCP00000031836	APC_basic domain-containing protein.	Catenin beta 1.	0.997
APC	FRAT1	ENSSSCP00000037698	ENSSSCP00000038733	APC_basic domain-containing protein.	Uncharacterized protein.	0.465
APC	FRAT2	ENSSSCP00000037698	ENSSSCP00000053206	APC_basic domain-containing protein.	FRAT regulator of WNT signaling pathway 2.	0.465
APC	GSK3B	ENSSSCP00000037698	ENSSSCP00000046229	APC_basic domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.994
APC	PPP2CA	ENSSSCP00000037698	ENSSSCP00000015208	APC_basic domain-containing protein.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	0.529