(13 nodes) GRB2 events in ERBB2 signaling network (Sus scrofa)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	NRG1	Neuregulin 1. (712 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1201 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NRG3	Neuregulin 3. (718 aa)
	BTC	EGF-like domain-containing protein. (342 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	HBEGF	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
	EREG	Epiregulin. (168 aa)
	NRG2	Neuregulin 2. (858 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTC	ERBB2	ENSSSCP00000036969	ENSSSCP00000018545	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.739
BTC	ERBB4	ENSSSCP00000036969	ENSSSCP00000017120	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.984
BTC	EREG	ENSSSCP00000036969	ENSSSCP00000067883	EGF-like domain-containing protein.	Epiregulin.	0.835
BTC	GRB2	ENSSSCP00000036969	ENSSSCP00000018229	EGF-like domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.489
BTC	HBEGF	ENSSSCP00000036969	ENSSSCP00000060087	EGF-like domain-containing protein.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.834
BTC	HRAS	ENSSSCP00000036969	ENSSSCP00000051149	EGF-like domain-containing protein.	HRas proto-oncogene, GTPase.	0.511
BTC	KRAS	ENSSSCP00000036969	ENSSSCP00000021836	EGF-like domain-containing protein.	KRAS proto-oncogene, GTPase.	0.529
BTC	NRAS	ENSSSCP00000036969	ENSSSCP00000046185	EGF-like domain-containing protein.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.511
BTC	NRG1	ENSSSCP00000036969	ENSSSCP00000042068	EGF-like domain-containing protein.	Neuregulin 1.	0.710
BTC	NRG2	ENSSSCP00000036969	ENSSSCP00000068052	EGF-like domain-containing protein.	Neuregulin 2.	0.712
BTC	NRG3	ENSSSCP00000036969	ENSSSCP00000031677	EGF-like domain-containing protein.	Neuregulin 3.	0.422
BTC	SOS1	ENSSSCP00000036969	ENSSSCP00000009045	EGF-like domain-containing protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.403
ERBB2	BTC	ENSSSCP00000018545	ENSSSCP00000036969	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.739
ERBB2	ERBB4	ENSSSCP00000018545	ENSSSCP00000017120	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.991
ERBB2	EREG	ENSSSCP00000018545	ENSSSCP00000067883	Receptor protein-tyrosine kinase.	Epiregulin.	0.893
ERBB2	GRB2	ENSSSCP00000018545	ENSSSCP00000018229	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.984
ERBB2	HBEGF	ENSSSCP00000018545	ENSSSCP00000060087	Receptor protein-tyrosine kinase.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.806
ERBB2	HRAS	ENSSSCP00000018545	ENSSSCP00000051149	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase.	0.804
ERBB2	KRAS	ENSSSCP00000018545	ENSSSCP00000021836	Receptor protein-tyrosine kinase.	KRAS proto-oncogene, GTPase.	0.861
ERBB2	NRAS	ENSSSCP00000018545	ENSSSCP00000046185	Receptor protein-tyrosine kinase.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.806