14 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HBEGF	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
	EREG	Epiregulin. (168 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)
	NRG2	Neuregulin 2. (858 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1201 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1342 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	GAB1	GRB2 associated binding protein 1. (723 aa)
	NRG3	Neuregulin 3. (718 aa)
	BTC	EGF-like domain-containing protein. (342 aa)
	NRG1	Neuregulin 1. (712 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTC	EGFR	ENSSSCP00000036969	ENSSSCP00000068369	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.983
BTC	ERBB2	ENSSSCP00000036969	ENSSSCP00000018545	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.739
BTC	ERBB3	ENSSSCP00000036969	ENSSSCP00000019799	EGF-like domain-containing protein.	Erb-b2 receptor tyrosine kinase 3.	0.924
BTC	ERBB4	ENSSSCP00000036969	ENSSSCP00000017120	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.984
BTC	EREG	ENSSSCP00000036969	ENSSSCP00000067883	EGF-like domain-containing protein.	Epiregulin.	0.835
BTC	GAB1	ENSSSCP00000036969	ENSSSCP00000029177	EGF-like domain-containing protein.	GRB2 associated binding protein 1.	0.499
BTC	GRB2	ENSSSCP00000036969	ENSSSCP00000018229	EGF-like domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.489
BTC	HBEGF	ENSSSCP00000036969	ENSSSCP00000060087	EGF-like domain-containing protein.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.834
BTC	NRG1	ENSSSCP00000036969	ENSSSCP00000042068	EGF-like domain-containing protein.	Neuregulin 1.	0.710
BTC	NRG2	ENSSSCP00000036969	ENSSSCP00000068052	EGF-like domain-containing protein.	Neuregulin 2.	0.712
BTC	NRG3	ENSSSCP00000036969	ENSSSCP00000031677	EGF-like domain-containing protein.	Neuregulin 3.	0.422
BTC	PIK3CA	ENSSSCP00000036969	ENSSSCP00000052984	EGF-like domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.520
BTC	PIK3R1	ENSSSCP00000036969	ENSSSCP00000024885	EGF-like domain-containing protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.499
EGFR	BTC	ENSSSCP00000068369	ENSSSCP00000036969	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.983
EGFR	ERBB2	ENSSSCP00000068369	ENSSSCP00000018545	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSSSCP00000068369	ENSSSCP00000019799	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.982
EGFR	ERBB4	ENSSSCP00000068369	ENSSSCP00000017120	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.889
EGFR	EREG	ENSSSCP00000068369	ENSSSCP00000067883	Receptor protein-tyrosine kinase.	Epiregulin.	0.998
EGFR	GAB1	ENSSSCP00000068369	ENSSSCP00000029177	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.983
EGFR	GRB2	ENSSSCP00000068369	ENSSSCP00000018229	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.999