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| | LOC100521680 | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | SOX13 | SRY-box transcription factor 13. (676 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | TCF7L1 | HMG box domain-containing protein. (412 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | PSMA2 | Proteasome endopeptidase complex. (243 aa) |
| | ZNRF3 | Zinc and ring finger 3. (912 aa) |
| | PSMC5 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa) |
| | PSMA4 | Proteasome subunit alpha type. (281 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | PSMA3 | Proteasome subunit alpha type. (275 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (419 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (659 aa) |
| | PSMB6 | Uncharacterized protein. (334 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (145 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | RSPO2 | Uncharacterized protein. (242 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (476 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | LOC100152135 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC100152878 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | PSME1 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa) |
| | PSMB11 | Proteasome subunit beta. (291 aa) |
| | PSMC1 | 26S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (808 aa) |
| | PSMB7 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | SOX17 | SRY-box transcription factor 17. (407 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (380 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | LOC102159655 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | PSMA5 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (223 aa) |
| | RSPO4 | R-spondin 4. (235 aa) |
| | CREBBP | CREB-binding protein isoform a. (2440 aa) |
| | F1RWC9_PIG | Histone domain-containing protein. (142 aa) |
| | H2AFZ | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC100155267 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa) |
| | DKK1 | Dickkopf_N domain-containing protein. (357 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1316 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (450 aa) |
| | RYK | Receptor like tyrosine kinase. (566 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | MEN1 | Menin 1. (704 aa) |
| | LGR4 | Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa) |
| | RBBP5 | RB binding protein 5, histone lysine methyltransferase complex subunit. (517 aa) |
| | PSMC2 | AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (534 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (421 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (794 aa) |
| | ASH2L | ASH2 like, histone lysine methyltransferase complex subunit. (635 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | I3LAJ9_PIG | Histone H2B; Belongs to the histone H2B family. (168 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa) |
| | HIST1H2BD | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SOX3 | SRY-box transcription factor 3. (448 aa) |
| | PSMF1 | Uncharacterized protein. (351 aa) |
| | LOC100158121 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | SRY | Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity). (236 aa) |
| | DVL3 | Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | LOC100621389 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | CSNK2B | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1108 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | RSPO3 | Uncharacterized protein. (280 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (774 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | A0A286ZRB3_PIG | Histone domain-containing protein. (130 aa) |
| | A0A286ZS34_PIG | Uncharacterized protein. (179 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1115 aa) |
| | LRTM1 | Leucine-rich repeat and transmembrane domain-containing protein 1 isoform 1. (345 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa) |
| | LOC100523244 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | FRAT1 | Uncharacterized protein. (279 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (428 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (514 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (149 aa) |
| | SOX7 | Transcription factor SOX-7. (389 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa) |
| | CTNNBIP1 | Beta-catenin-interacting protein 1. (81 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | SOX6 | SRY-box transcription factor 6. (859 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | USP34 | Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3522 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1602 aa) |
| | CSNK2A2 | Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3858 aa) |
| | LEO1 | LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | SOST | Sclerostin. (212 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa) |
| | PSME4 | Proteasome activator complex subunit 4. (1843 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (748 aa) |
| | RSPO1 | R-spondin 1. (262 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (204 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (477 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | RBX1 | E3 ubiquitin-protein ligase RBX1. (108 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (351 aa) |
| | RNF43 | RING-type domain-containing protein. (743 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (145 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (228 aa) |
| | HIST1H3E | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | FZD8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa) |
| | LOC100620620 | Histone H2A; Belongs to the histone H2A family. (113 aa) |
| | AXIN2 | Axin-2. (843 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa) |
| | LGR5 | Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (614 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | KLHL12 | BTB domain-containing protein. (916 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (807 aa) |
| | RNF146 | Ring finger protein 146. (369 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSMB10 | Proteasome subunit beta. (296 aa) |
| | BCL9L | BCL9 like. (1526 aa) |
| | PSMA7 | Proteasome subunit alpha type. (267 aa) |
