(12 nodes) Metabolism of Angiotensinogen to Angiotensins network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	CES1-2	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (530 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (482 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (304 aa)
	AOPEP	Aminopeptidase O (putative). (840 aa)
	ACE	Angiotensin-converting enzyme. (1309 aa)
	I3LDA9_PIG	Peptidase S1 domain-containing protein. (236 aa)
	I3LP35_PIG	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	LOC100154047	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (353 aa)
	ENPEP	Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family. (944 aa)
	REN	Renin preproprotein; Belongs to the peptidase A1 family. (407 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSSSCP00000018326	ENSSSCP00000028755	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.571
ACE	AGT	ENSSSCP00000018326	ENSSSCP00000029872	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.989
ACE	ATP6AP2	ENSSSCP00000018326	ENSSSCP00000061026	Angiotensin-converting enzyme.	ATPase H+ transporting accessory protein 2.	0.560
ACE	ENPEP	ENSSSCP00000018326	ENSSSCP00000064005	Angiotensin-converting enzyme.	Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family.	0.543
ACE	LOC100154047	ENSSSCP00000018326	ENSSSCP00000054152	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.408
ACE	REN	ENSSSCP00000018326	ENSSSCP00000045910	Angiotensin-converting enzyme.	Renin preproprotein; Belongs to the peptidase A1 family.	0.954
ACE2	ACE	ENSSSCP00000028755	ENSSSCP00000018326	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.571
ACE2	AGT	ENSSSCP00000028755	ENSSSCP00000029872	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.992
ACE2	ATP6AP2	ENSSSCP00000028755	ENSSSCP00000061026	Angiotensin-converting enzyme.	ATPase H+ transporting accessory protein 2.	0.565
ACE2	ENPEP	ENSSSCP00000028755	ENSSSCP00000064005	Angiotensin-converting enzyme.	Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family.	0.629
ACE2	I3LDA9_PIG	ENSSSCP00000028755	ENSSSCP00000022038	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein.	0.404
ACE2	LOC100154047	ENSSSCP00000028755	ENSSSCP00000054152	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.467
ACE2	REN	ENSSSCP00000028755	ENSSSCP00000045910	Angiotensin-converting enzyme.	Renin preproprotein; Belongs to the peptidase A1 family.	0.953
AGT	ACE	ENSSSCP00000029872	ENSSSCP00000018326	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.989
AGT	ACE2	ENSSSCP00000029872	ENSSSCP00000028755	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.992
AGT	AOPEP	ENSSSCP00000029872	ENSSSCP00000011669	Angiotensinogen; Belongs to the serpin family.	Aminopeptidase O (putative).	0.751
AGT	ATP6AP2	ENSSSCP00000029872	ENSSSCP00000061026	Angiotensinogen; Belongs to the serpin family.	ATPase H+ transporting accessory protein 2.	0.906
AGT	CTSZ	ENSSSCP00000029872	ENSSSCP00000008030	Angiotensinogen; Belongs to the serpin family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.802
AGT	ENPEP	ENSSSCP00000029872	ENSSSCP00000064005	Angiotensinogen; Belongs to the serpin family.	Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family.	0.889
AGT	I3LDA9_PIG	ENSSSCP00000029872	ENSSSCP00000022038	Angiotensinogen; Belongs to the serpin family.	Peptidase S1 domain-containing protein.	0.806