STRINGSTRING
A0A287AC24_PIG A0A287AC24_PIG HLA-DRA HLA-DRA PSMB9 PSMB9 NFKBIA NFKBIA PSME1 PSME1 PSMB11 PSMB11 PSMC1 PSMC1 PSMA8 PSMA8 PSMB7 PSMB7 PSMD4 PSMD4 PSMA5 PSMA5 BCL10 BCL10 PTEN PTEN CHUK CHUK PRKCQ PRKCQ PSMD6 PSMD6 RELA RELA KXD1 KXD1 PSMC2 PSMC2 PSMD1 PSMD1 PSMD3 PSMD3 PSMD11 PSMD11 CD4 CD4 I3LAQ5_PIG I3LAQ5_PIG PSMF1 PSMF1 TRAT1 TRAT1 PIK3R1 PIK3R1 RIPK2 RIPK2 CD3D CD3D MALT1 MALT1 A0A286ZKB7_PIG A0A286ZKB7_PIG PSMD9 PSMD9 PSMB3 PSMB3 TRAF6 TRAF6 A0A286ZS34_PIG A0A286ZS34_PIG PDPK1 PDPK1 TAB2 TAB2 PSMD12 PSMD12 CARD11 CARD11 A0A287AAB9_PIG A0A287AAB9_PIG INPP5D INPP5D A0A287BPL5_PIG A0A287BPL5_PIG PSMB1 PSMB1 A0A287BQ00_PIG A0A287BQ00_PIG A0A287BQ31_PIG A0A287BQ31_PIG PSMB10 PSMB10 PSMA7 PSMA7 PSMD10 PSMD10 PIK3R2 PIK3R2 PSMA1 PSMA1 PSMD5 PSMD5 UBC UBC PSMA2 PSMA2 UBE2V1 UBE2V1 PSMC5 PSMC5 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 PSMD13 PSMD13 PSMC3 PSMC3 PSMB6 PSMB6 SLA-DQA1 SLA-DQA1 UBE2N UBE2N PSME3 PSME3 PSMD7 PSMD7 CD3G CD3G LCK LCK PSME4 PSME4 A0A287ARF7_PIG A0A287ARF7_PIG A0A287AT33_PIG A0A287AT33_PIG NFKB1 NFKB1 IKBKG IKBKG RPS27A RPS27A LOC102158035 LOC102158035 PSMC4 PSMC4 PSMD8 PSMD8 PIK3CB PIK3CB PIK3CA PIK3CA PSMC6 PSMC6 SLA-DRB1 SLA-DRB1 MAP3K7 MAP3K7 PSMD14 PSMD14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A287AC24_PIGIg-like domain-containing protein. (112 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa)
PSMB9Proteasome subunit beta. (219 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMB11Proteasome subunit beta. (291 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
BCL10B-cell lymphoma/leukemia 10 isoform 1. (233 aa)
PTENUncharacterized protein. (576 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
RELATranscription factor p65 isoform 1. (573 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
CD4CD4 molecule. (494 aa)
I3LAQ5_PIGIg-like domain-containing protein. (164 aa)
PSMF1Uncharacterized protein. (351 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (181 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
CD3DT-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
A0A286ZKB7_PIGIg-like domain-containing protein. (259 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMB3Proteasome subunit beta. (205 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (692 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
A0A287AAB9_PIGIg-like domain-containing protein. (252 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
A0A287BPL5_PIGIg-like domain-containing protein. (154 aa)
PSMB1Proteasome subunit beta. (241 aa)
A0A287BQ00_PIGIg-like domain-containing protein. (194 aa)
A0A287BQ31_PIGIg-like domain-containing protein. (180 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PIK3R2Uncharacterized protein. (772 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (170 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
SLA-DQA1SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa)
UBE2NUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (147 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
LCKTyrosine-protein kinase. (520 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
A0A287ARF7_PIGIg-like domain-containing protein. (139 aa)
A0A287AT33_PIGIg-like domain-containing protein. (173 aa)
NFKB1Uncharacterized protein. (898 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
LOC102158035Ig-like domain-containing protein. (268 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
SLA-DRB1Ig-like domain-containing protein. (307 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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