(18 nodes) Signaling by Hippo network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MOB1B	MOB kinase activator 1B. (242 aa)
	WWTR1	WW domain containing transcription regulator 1. (398 aa)
	DVL2	Dishevelled segment polarity protein 2. (794 aa)
	NPHP4	Nephrocystin 4. (1466 aa)
	AMOT	Angiomotin isoform X1. (1088 aa)
	SAV1	Salvador family WW domain containing protein 1. (433 aa)
	YAP1	Yes associated protein 1. (432 aa)
	LATS1	Large tumor suppressor kinase 1. (1146 aa)
	STK3	Serine/threonine kinase 3. (542 aa)
	MOB1A	MOB kinase activator 1A. (214 aa)
	AMOTL1	Angiomotin-like protein 1 isoform X1. (990 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1187 aa)
	LATS2	Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1862 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
	WWC1	WW and C2 domain containing 1. (1114 aa)
	AMOTL2	Angiomotin like 2. (732 aa)
	STK4	Serine/threonine kinase 4. (502 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOT	AMOTL1	ENSSSCP00000030639	ENSSSCP00000052243	Angiomotin isoform X1.	Angiomotin-like protein 1 isoform X1.	0.945
AMOT	AMOTL2	ENSSSCP00000030639	ENSSSCP00000061035	Angiomotin isoform X1.	Angiomotin like 2.	0.917
AMOT	DVL2	ENSSSCP00000030639	ENSSSCP00000019910	Angiomotin isoform X1.	Dishevelled segment polarity protein 2.	0.522
AMOT	LATS1	ENSSSCP00000030639	ENSSSCP00000044445	Angiomotin isoform X1.	Large tumor suppressor kinase 1.	0.918
AMOT	LATS2	ENSSSCP00000030639	ENSSSCP00000054512	Angiomotin isoform X1.	Serine/threonine-protein kinase LATS2 isoform X1.	0.875
AMOT	MOB1A	ENSSSCP00000030639	ENSSSCP00000048882	Angiomotin isoform X1.	MOB kinase activator 1A.	0.599
AMOT	MOB1B	ENSSSCP00000030639	ENSSSCP00000070864	Angiomotin isoform X1.	MOB kinase activator 1B.	0.635
AMOT	SAV1	ENSSSCP00000030639	ENSSSCP00000031153	Angiomotin isoform X1.	Salvador family WW domain containing protein 1.	0.747
AMOT	STK3	ENSSSCP00000030639	ENSSSCP00000047780	Angiomotin isoform X1.	Serine/threonine kinase 3.	0.563
AMOT	STK4	ENSSSCP00000030639	ENSSSCP00000072223	Angiomotin isoform X1.	Serine/threonine kinase 4.	0.605
AMOT	WWC1	ENSSSCP00000030639	ENSSSCP00000060132	Angiomotin isoform X1.	WW and C2 domain containing 1.	0.426
AMOT	WWTR1	ENSSSCP00000030639	ENSSSCP00000012476	Angiomotin isoform X1.	WW domain containing transcription regulator 1.	0.957
AMOT	YAP1	ENSSSCP00000030639	ENSSSCP00000033204	Angiomotin isoform X1.	Yes associated protein 1.	0.979
AMOT	YWHAB	ENSSSCP00000030639	ENSSSCP00000058156	Angiomotin isoform X1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.635
AMOTL1	AMOT	ENSSSCP00000052243	ENSSSCP00000030639	Angiomotin-like protein 1 isoform X1.	Angiomotin isoform X1.	0.945
AMOTL1	AMOTL2	ENSSSCP00000052243	ENSSSCP00000061035	Angiomotin-like protein 1 isoform X1.	Angiomotin like 2.	0.916
AMOTL1	DVL2	ENSSSCP00000052243	ENSSSCP00000019910	Angiomotin-like protein 1 isoform X1.	Dishevelled segment polarity protein 2.	0.522
AMOTL1	LATS1	ENSSSCP00000052243	ENSSSCP00000044445	Angiomotin-like protein 1 isoform X1.	Large tumor suppressor kinase 1.	0.838
AMOTL1	LATS2	ENSSSCP00000052243	ENSSSCP00000054512	Angiomotin-like protein 1 isoform X1.	Serine/threonine-protein kinase LATS2 isoform X1.	0.815
AMOTL1	MOB1A	ENSSSCP00000052243	ENSSSCP00000048882	Angiomotin-like protein 1 isoform X1.	MOB kinase activator 1A.	0.566