STRINGSTRING
A0A287A4Y3_PIG A0A287A4Y3_PIG A0A287A9X3_PIG A0A287A9X3_PIG ACTG1 ACTG1 A0A287AEB1_PIG A0A287AEB1_PIG WIPF1 WIPF1 CD3G CD3G NCKAP1 NCKAP1 A0A287AM45_PIG A0A287AM45_PIG MAPK1 MAPK1 WASF1 WASF1 HSP90AA1 HSP90AA1 A0A287AU93_PIG A0A287AU93_PIG CYFIP2 CYFIP2 PLD4 PLD4 PIK3CB PIK3CB PIK3CA PIK3CA A0A287BAB3_PIG A0A287BAB3_PIG ABL1 ABL1 PRKCD PRKCD FCGR1A FCGR1A A0A287BH28_PIG A0A287BH28_PIG A0A287BHK5_PIG A0A287BHK5_PIG BAIAP2 BAIAP2 A0A287BLH9_PIG A0A287BLH9_PIG MAPK3 MAPK3 LAC_PIG LAC_PIG A0A287BNX9_PIG A0A287BNX9_PIG A0A287BRE1_PIG A0A287BRE1_PIG HCK HCK PIK3R2 PIK3R2 A0A5G2Q8Z5_PIG A0A5G2Q8Z5_PIG WASL WASL YES1 YES1 RAC1 RAC1 PLPP5 PLPP5 PLPP4 PLPP4 NCKAP1L NCKAP1L VAV3 VAV3 VAV2 VAV2 LIMK1 LIMK1 MYO10 MYO10 PLCG2 PLCG2 FGR FGR FYN FYN LYN LYN PLCG1 PLCG1 ARPC1A ARPC1A PRKCE PRKCE F1S9H7_PIG F1S9H7_PIG WASF3 WASF3 ARPC3 ARPC3 NF2 NF2 LOC100523213 LOC100523213 ABI1 ABI1 NCKIPSD NCKIPSD BRK1 BRK1 MYO9B MYO9B ARPC5 ARPC5 ACTR3 ACTR3 GRB2 GRB2 PLD2 PLD2 I3LBK0_PIG I3LBK0_PIG WASF2 WASF2 PIK3R1 PIK3R1 F1STC2_PIG F1STC2_PIG NCK1 NCK1 ELMO2 ELMO2 FCGR2B FCGR2B A0A075B7H8_PIG A0A075B7H8_PIG CDC42 CDC42 SRC SRC PAK1 PAK1 A0A286ZJL9_PIG A0A286ZJL9_PIG HSP90AB1 HSP90AB1 MYO1C MYO1C ARPC1B ARPC1B A0A286ZP42_PIG A0A286ZP42_PIG A0A286ZQH2_PIG A0A286ZQH2_PIG VAV1 VAV1 A0A286ZRV9_PIG A0A286ZRV9_PIG CRK CRK ACTB ACTB PLA2G6 PLA2G6 ARPC4 ARPC4 ACTR2 ACTR2 PLD1 PLD1 ARPC2 ARPC2 ABI2 ABI2 DOCK1 DOCK1 A0A287A3T6_PIG A0A287A3T6_PIG LOC100623670 LOC100623670
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A287A4Y3_PIGIg-like domain-containing protein. (226 aa)
A0A287A9X3_PIGIGv domain-containing protein. (120 aa)
ACTG1Actin gamma 1. (381 aa)
A0A287AEB1_PIGIg-like domain-containing protein. (106 aa)
WIPF1WH2 domain-containing protein. (515 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
NCKAP1NCK associated protein 1. (1134 aa)
A0A287AM45_PIGIg-like domain-containing protein. (282 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
WASF1WH2 domain-containing protein. (559 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
A0A287AU93_PIGIg-like domain-containing protein. (216 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PLD4Phospholipase D family member 4. (684 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
A0A287BAB3_PIGIg-like domain-containing protein. (169 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
FCGR1AUncharacterized protein. (362 aa)
A0A287BH28_PIGIg-like domain-containing protein. (185 aa)
A0A287BHK5_PIGIg-like domain-containing protein. (125 aa)
BAIAP2BAI1 associated protein 2. (575 aa)
A0A287BLH9_PIGUncharacterized protein. (221 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LAC_PIGIg lambda chain C region. (380 aa)
A0A287BNX9_PIGIg-like domain-containing protein. (111 aa)
A0A287BRE1_PIGIg-like domain-containing protein. (112 aa)
HCKTyrosine-protein kinase. (527 aa)
PIK3R2Uncharacterized protein. (772 aa)
A0A5G2Q8Z5_PIGIg-like domain-containing protein. (131 aa)
WASLWASP like actin nucleation promoting factor. (511 aa)
YES1Tyrosine-protein kinase. (553 aa)
RAC1Rac family small GTPase 1. (186 aa)
PLPP5Phospholipid phosphatase 5. (263 aa)
PLPP4Phospholipid phosphatase 4. (346 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
LIMK1LIM domain kinase 1. (681 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
FGRTyrosine-protein kinase. (537 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
LYNTyrosine-protein kinase. (512 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
F1S9H7_PIGIg-like domain-containing protein. (158 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NF2Neurofibromin 2. (586 aa)
LOC100523213Ig-like domain-containing protein. (212 aa)
ABI1Abl interactor 1 isoform b. (481 aa)
NCKIPSDNCK interacting protein with SH3 domain. (715 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (103 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (422 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
PLD2Phospholipase. (933 aa)
I3LBK0_PIGIg-like domain-containing protein. (218 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
F1STC2_PIGIg-like domain-containing protein. (216 aa)
NCK1Cytoplasmic protein. (377 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
FCGR2BUncharacterized protein. (434 aa)
A0A075B7H8_PIGIg-like domain-containing protein. (101 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
SRCTyrosine-protein kinase. (559 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
A0A286ZJL9_PIGUncharacterized protein. (498 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (825 aa)
MYO1CUnconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (440 aa)
A0A286ZP42_PIGIGv domain-containing protein. (147 aa)
A0A286ZQH2_PIGIg-like domain-containing protein. (111 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
A0A286ZRV9_PIGIg-like domain-containing protein. (192 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (231 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (404 aa)
PLD1Phospholipase. (1074 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa)
ABI2Abl interactor 2. (542 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
A0A287A3T6_PIGIg-like domain-containing protein. (156 aa)
LOC100623670Ig-like domain-containing protein. (315 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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