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CDC42 CDC42 ARPC1A ARPC1A F1S9H7_PIG F1S9H7_PIG WASF3 WASF3 ARPC3 ARPC3 NF2 NF2 LOC100523213 LOC100523213 ABI1 ABI1 NCKIPSD NCKIPSD BRK1 BRK1 MYO9B MYO9B ARPC5 ARPC5 ACTR3 ACTR3 GRB2 GRB2 I3LBK0_PIG I3LBK0_PIG WASF2 WASF2 F1STC2_PIG F1STC2_PIG NCK1 NCK1 ELMO2 ELMO2 FCGR2B FCGR2B A0A075B7H8_PIG A0A075B7H8_PIG PAK1 PAK1 A0A286ZJL9_PIG A0A286ZJL9_PIG HSP90AB1 HSP90AB1 MYO1C MYO1C ARPC1B ARPC1B A0A286ZP42_PIG A0A286ZP42_PIG A0A286ZQH2_PIG A0A286ZQH2_PIG VAV1 VAV1 A0A286ZRV9_PIG A0A286ZRV9_PIG CRK CRK ACTB ACTB ARPC4 ARPC4 ACTR2 ACTR2 ARPC2 ARPC2 ABI2 ABI2 DOCK1 DOCK1 A0A287A3T6_PIG A0A287A3T6_PIG LOC100623670 LOC100623670 A0A287A4Y3_PIG A0A287A4Y3_PIG A0A287A9X3_PIG A0A287A9X3_PIG ACTG1 ACTG1 A0A287AEB1_PIG A0A287AEB1_PIG WIPF1 WIPF1 CD3G CD3G NCKAP1 NCKAP1 A0A287AM45_PIG A0A287AM45_PIG WASF1 WASF1 HSP90AA1 HSP90AA1 A0A287AU93_PIG A0A287AU93_PIG CYFIP2 CYFIP2 A0A287BAB3_PIG A0A287BAB3_PIG ABL1 ABL1 FCGR1A FCGR1A A0A287BH28_PIG A0A287BH28_PIG A0A287BHK5_PIG A0A287BHK5_PIG BAIAP2 BAIAP2 A0A287BLH9_PIG A0A287BLH9_PIG MAPK3 MAPK3 LAC_PIG LAC_PIG A0A287BNX9_PIG A0A287BNX9_PIG A0A287BRE1_PIG A0A287BRE1_PIG A0A5G2Q8Z5_PIG A0A5G2Q8Z5_PIG WASL WASL RAC1 RAC1 NCKAP1L NCKAP1L VAV3 VAV3 VAV2 VAV2 MYO10 MYO10 LIMK1 LIMK1 MAPK1 MAPK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
F1S9H7_PIGIg-like domain-containing protein. (158 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NF2Neurofibromin 2. (586 aa)
LOC100523213Ig-like domain-containing protein. (212 aa)
ABI1Abl interactor 1 isoform b. (481 aa)
NCKIPSDNCK interacting protein with SH3 domain. (715 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (103 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (422 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
I3LBK0_PIGIg-like domain-containing protein. (218 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
F1STC2_PIGIg-like domain-containing protein. (216 aa)
NCK1Cytoplasmic protein. (377 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
FCGR2BUncharacterized protein. (434 aa)
A0A075B7H8_PIGIg-like domain-containing protein. (101 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
A0A286ZJL9_PIGUncharacterized protein. (498 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (825 aa)
MYO1CUnconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (440 aa)
A0A286ZP42_PIGIGv domain-containing protein. (147 aa)
A0A286ZQH2_PIGIg-like domain-containing protein. (111 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
A0A286ZRV9_PIGIg-like domain-containing protein. (192 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (231 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (404 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa)
ABI2Abl interactor 2. (542 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
A0A287A3T6_PIGIg-like domain-containing protein. (156 aa)
LOC100623670Ig-like domain-containing protein. (315 aa)
A0A287A4Y3_PIGIg-like domain-containing protein. (226 aa)
A0A287A9X3_PIGIGv domain-containing protein. (120 aa)
ACTG1Actin gamma 1. (381 aa)
A0A287AEB1_PIGIg-like domain-containing protein. (106 aa)
WIPF1WH2 domain-containing protein. (515 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
NCKAP1NCK associated protein 1. (1134 aa)
A0A287AM45_PIGIg-like domain-containing protein. (282 aa)
WASF1WH2 domain-containing protein. (559 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
A0A287AU93_PIGIg-like domain-containing protein. (216 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
A0A287BAB3_PIGIg-like domain-containing protein. (169 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
FCGR1AUncharacterized protein. (362 aa)
A0A287BH28_PIGIg-like domain-containing protein. (185 aa)
A0A287BHK5_PIGIg-like domain-containing protein. (125 aa)
BAIAP2BAI1 associated protein 2. (575 aa)
A0A287BLH9_PIGUncharacterized protein. (221 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LAC_PIGIg lambda chain C region. (380 aa)
A0A287BNX9_PIGIg-like domain-containing protein. (111 aa)
A0A287BRE1_PIGIg-like domain-containing protein. (112 aa)
A0A5G2Q8Z5_PIGIg-like domain-containing protein. (131 aa)
WASLWASP like actin nucleation promoting factor. (511 aa)
RAC1Rac family small GTPase 1. (186 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
LIMK1LIM domain kinase 1. (681 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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