(39 nodes) Cytochrome P450 - arranged by substrate type network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (538 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
	TBXAS1	Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)
	CYP27A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (581 aa)
	AHR	Aryl hydrocarbon receptor. (849 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...] (520 aa)
	CYP4F22	Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
	CYP2J34	Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (892 aa)
	FDX1	Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family. (186 aa)
	CYP7A1	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa)
	CYP2U1	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (650 aa)
	CYP2R1	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (500 aa)
	CYP51A1	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (503 aa)
	NCOA2	Nuclear receptor coactivator. (1463 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
	AHRR	Uncharacterized protein. (695 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial. (520 aa)
	CYP4V2	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	CYP4F3	Cytochrome P450 family 4 subfamily F member 3; Belongs to the cytochrome P450 family. (524 aa)
	CYP39A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa)
	CYP21A2	Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (526 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (509 aa)
	RXRA	Retinoid X receptor alpha. (701 aa)
	CYP46A1	Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa)
	CYP2A19	Cytochorme P450 2A19; Belongs to the cytochrome P450 family. (494 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (492 aa)
	CYP2B22	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	CYP4A24	Cytochrome P450 4A24; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid; Belongs to the cytochrome P450 family. (482 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
	PTGIS	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
	CYP24A1	25-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa)
	CYP2W1	Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (469 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	AHRR	ENSSSCP00000022722	ENSSSCP00000044912	Aryl hydrocarbon receptor.	Uncharacterized protein.	0.554
AHR	ARNT2	ENSSSCP00000022722	ENSSSCP00000032544	Aryl hydrocarbon receptor.	Aryl hydrocarbon receptor nuclear translocator 2.	0.950
AHR	NCOA2	ENSSSCP00000022722	ENSSSCP00000042311	Aryl hydrocarbon receptor.	Nuclear receptor coactivator.	0.532
AHRR	AHR	ENSSSCP00000044912	ENSSSCP00000022722	Uncharacterized protein.	Aryl hydrocarbon receptor.	0.554
AHRR	ARNT2	ENSSSCP00000044912	ENSSSCP00000032544	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator 2.	0.858
AHRR	CYP1A1	ENSSSCP00000044912	ENSSSCP00000002085	Uncharacterized protein.	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.699
AHRR	CYP1B1	ENSSSCP00000044912	ENSSSCP00000056236	Uncharacterized protein.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.635
AHRR	NCOA2	ENSSSCP00000044912	ENSSSCP00000042311	Uncharacterized protein.	Nuclear receptor coactivator.	0.532
ARNT2	AHR	ENSSSCP00000032544	ENSSSCP00000022722	Aryl hydrocarbon receptor nuclear translocator 2.	Aryl hydrocarbon receptor.	0.950
ARNT2	AHRR	ENSSSCP00000032544	ENSSSCP00000044912	Aryl hydrocarbon receptor nuclear translocator 2.	Uncharacterized protein.	0.858
CYP11A1	CYP1A1	ENSSSCP00000023389	ENSSSCP00000002085	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.453
CYP11A1	CYP1A2	ENSSSCP00000023389	ENSSSCP00000002079	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.428
CYP11A1	CYP1B1	ENSSSCP00000023389	ENSSSCP00000056236	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.421
CYP11A1	CYP21A2	ENSSSCP00000023389	ENSSSCP00000062899	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.	0.575
CYP11A1	CYP26B1	ENSSSCP00000023389	ENSSSCP00000008873	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.703
CYP11A1	CYP26C1	ENSSSCP00000023389	ENSSSCP00000011163	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family.	0.585
CYP11A1	CYP2R1	ENSSSCP00000023389	ENSSSCP00000041374	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.408
CYP11A1	CYP46A1	ENSSSCP00000023389	ENSSSCP00000002717	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family.	0.477
CYP11A1	CYP4V2	ENSSSCP00000023389	ENSSSCP00000050035	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family.	0.464
CYP11A1	CYP7B1	ENSSSCP00000023389	ENSSSCP00000006632	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...]	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.940