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CES1-2 CES1-2 CYP2A19 CYP2A19 CYP2F1 CYP2F1 CYP2B22 CYP2B22 CYP4A24 CYP4A24 ALDH1B1 ALDH1B1 CYP7B1 CYP7B1 SMOX SMOX PTGIS PTGIS CYP24A1 CYP24A1 CYP2W1 CYP2W1 CYP26B1 CYP26B1 ADH4 ADH4 PTGES3 PTGES3 BPHL BPHL CYP1A2 CYP1A2 CYP1A1 CYP1A1 CYP46A1 CYP46A1 CYP4B1 CYP4B1 AHRR AHRR PTGS1 PTGS1 FDXR FDXR ACSS1 ACSS1 AADAC AADAC ADH5 ADH5 CYP4V2 CYP4V2 FMO1 FMO1 MTARC1 MTARC1 ACSS2 ACSS2 FMO3 FMO3 CYP1B1 CYP1B1 CYP4F3 CYP4F3 CYP39A1 CYP39A1 ADH1C ADH1C CYP21A2 CYP21A2 NR1H4 NR1H4 CYB5B CYB5B CES3 CES3 RXRA RXRA LOC110256000 LOC110256000 ALDH2 ALDH2 CYP26C1 CYP26C1 CYP26A1 CYP26A1 EPHX1 EPHX1 CBR3 CBR3 AIP AIP FMO2 FMO2 TBXAS1 TBXAS1 AOC2 AOC2 CYP27A1 CYP27A1 AHR AHR CYP27B1 CYP27B1 CYP11A1 CYP11A1 CYP4F22 CYP4F22 ALDH1A1 ALDH1A1 CYP2J34 CYP2J34 NQO2 NQO2 HSP90AB1 HSP90AB1 ARNT2 ARNT2 LOC100520329 LOC100520329 ALDH3A1 ALDH3A1 FDX1 FDX1 CYP7A1 CYP7A1 CYP2U1 CYP2U1 AOC1 AOC1 PAOX PAOX CMBL CMBL CYP2S1 CYP2S1 CYP2R1 CYP2R1 CYP51A1 CYP51A1 NCOA2 NCOA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CES1-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (530 aa)
CYP2A19Cytochorme P450 2A19; Belongs to the cytochrome P450 family. (494 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (492 aa)
CYP2B22Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
CYP4A24Cytochrome P450 4A24; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid; Belongs to the cytochrome P450 family. (482 aa)
ALDH1B1Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family. (517 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
SMOXSpermine oxidase. (585 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
CYP24A125-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (469 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ADH4Alcohol dehydrogenase 4 isoform 2. (380 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
BPHLAB hydrolase-1 domain-containing protein. (309 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (538 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
AHRRUncharacterized protein. (695 aa)
PTGS1Prostaglandin G/H synthase 1 isoform 1. (600 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (520 aa)
ACSS1Acetyl-coenzyme A synthetase. (703 aa)
AADACArylacetamide deacetylase. (399 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (392 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (554 aa)
MTARC1Mitochondrial amidoxime-reducing component 1. (341 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
CYP4F3Cytochrome P450 family 4 subfamily F member 3; Belongs to the cytochrome P450 family. (524 aa)
CYP39A1Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa)
ADH1CPKS_ER domain-containing protein. (388 aa)
CYP21A2Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (526 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (509 aa)
CYB5BCytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (148 aa)
CES3Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (571 aa)
RXRARetinoid X receptor alpha. (701 aa)
LOC110256000Amine oxidase; Belongs to the copper/topaquinone oxidase family. (751 aa)
ALDH2Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. (537 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
EPHX1Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. (452 aa)
CBR3Carbonyl reductase NADPH 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
AIPAryl hydrocarbon receptor interacting protein. (330 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
TBXAS1Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)
AOC2Amine oxidase. (755 aa)
CYP27A1Uncharacterized protein; Belongs to the cytochrome P450 family. (581 aa)
AHRAryl hydrocarbon receptor. (849 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...] (520 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
CYP2J34Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa)
NQO2N-ribosyldihydronicotinamide:quinone reductase 2. (239 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (825 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (892 aa)
LOC100520329Amine oxidase. (742 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (527 aa)
FDX1Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family. (186 aa)
CYP7A1Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa)
AOC1Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis; Belongs to the copper/topaquinone oxidase family. (726 aa)
PAOXAmino_oxidase domain-containing protein. (512 aa)
CMBLCarboxymethylenebutenolidase homolog. (245 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (650 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (500 aa)
CYP51A1Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (503 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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