6 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HBEGF	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
	PLCG1	Phosphoinositide phospholipase C. (1379 aa)
	AREG	Amphiregulin long form. (247 aa)
	BTC	EGF-like domain-containing protein. (342 aa)
	EREG	Epiregulin. (168 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSSSCP00000009565	ENSSSCP00000036969	Amphiregulin long form.	EGF-like domain-containing protein.	0.949
AREG	EGFR	ENSSSCP00000009565	ENSSSCP00000068369	Amphiregulin long form.	Receptor protein-tyrosine kinase.	0.997
AREG	EREG	ENSSSCP00000009565	ENSSSCP00000067883	Amphiregulin long form.	Epiregulin.	0.974
AREG	HBEGF	ENSSSCP00000009565	ENSSSCP00000060087	Amphiregulin long form.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.725
AREG	PLCG1	ENSSSCP00000009565	ENSSSCP00000007834	Amphiregulin long form.	Phosphoinositide phospholipase C.	0.499
BTC	AREG	ENSSSCP00000036969	ENSSSCP00000009565	EGF-like domain-containing protein.	Amphiregulin long form.	0.949
BTC	EGFR	ENSSSCP00000036969	ENSSSCP00000068369	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.983
BTC	EREG	ENSSSCP00000036969	ENSSSCP00000067883	EGF-like domain-containing protein.	Epiregulin.	0.835
BTC	HBEGF	ENSSSCP00000036969	ENSSSCP00000060087	EGF-like domain-containing protein.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.834
BTC	PLCG1	ENSSSCP00000036969	ENSSSCP00000007834	EGF-like domain-containing protein.	Phosphoinositide phospholipase C.	0.522
EGFR	AREG	ENSSSCP00000068369	ENSSSCP00000009565	Receptor protein-tyrosine kinase.	Amphiregulin long form.	0.997
EGFR	BTC	ENSSSCP00000068369	ENSSSCP00000036969	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.983
EGFR	EREG	ENSSSCP00000068369	ENSSSCP00000067883	Receptor protein-tyrosine kinase.	Epiregulin.	0.998
EGFR	HBEGF	ENSSSCP00000068369	ENSSSCP00000060087	Receptor protein-tyrosine kinase.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.996
EGFR	PLCG1	ENSSSCP00000068369	ENSSSCP00000007834	Receptor protein-tyrosine kinase.	Phosphoinositide phospholipase C.	0.981
EREG	AREG	ENSSSCP00000067883	ENSSSCP00000009565	Epiregulin.	Amphiregulin long form.	0.974
EREG	BTC	ENSSSCP00000067883	ENSSSCP00000036969	Epiregulin.	EGF-like domain-containing protein.	0.835
EREG	EGFR	ENSSSCP00000067883	ENSSSCP00000068369	Epiregulin.	Receptor protein-tyrosine kinase.	0.998
EREG	HBEGF	ENSSSCP00000067883	ENSSSCP00000060087	Epiregulin.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.908
EREG	PLCG1	ENSSSCP00000067883	ENSSSCP00000007834	Epiregulin.	Phosphoinositide phospholipase C.	0.499