STRINGSTRING
ALOX15 ALOX15 PTGES3 PTGES3 LTA4H LTA4H CYP1A2 CYP1A2 CYP1A1 CYP1A1 GPX2 GPX2 CYP4A24 CYP4A24 PTGES2 PTGES2 PTGES PTGES PTGIS PTGIS HPGDS HPGDS PON2 PON2 MAPKAPK2 MAPKAPK2 TBXAS1 TBXAS1 ALOX15B ALOX15B ALOX12B ALOX12B ALOXE3 ALOXE3 DPEP1 DPEP1 DPEP3 DPEP3 LTC4S LTC4S CYP4F22 CYP4F22 CYP2J34 CYP2J34 ALOX5 ALOX5 PTGS2 PTGS2 CYP2U1 CYP2U1 PON3 PON3 EPHX2 EPHX2 ABCC1 ABCC1 AKR1C1 AKR1C1 CYP4B1 CYP4B1 PTGS1 PTGS1 GPX4 GPX4 PON1 PON1 FAAH FAAH DPEP2 DPEP2 CBR1 CBR1 CYP1B1 CYP1B1 CYP4F3 CYP4F3 PLA2G4A PLA2G4A GGT5 GGT5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (606 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (538 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
CYP4A24Cytochrome P450 4A24; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid; Belongs to the cytochrome P450 family. (482 aa)
PTGES2Prostaglandin E synthase 2. (372 aa)
PTGESMicrosomal prostaglandin E synthase-1. (153 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
PON2Serum paraoxonase/arylesterase 2 isoform 1. (354 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
TBXAS1Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (718 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (698 aa)
ALOXE3Arachidonate lipoxygenase 3. (710 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (555 aa)
LTC4SLeukotriene C4 synthase. (146 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
CYP2J34Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa)
PON3Paraoxonase 3. (354 aa)
EPHX2Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N- terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12- phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (575 aa)
ABCC1ATP binding cassette subfamily C member 1. (1532 aa)
AKR1C1Aldo-keto reductase family 1 member C3 isoform 2. (324 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
PTGS1Prostaglandin G/H synthase 1 isoform 1. (600 aa)
GPX4Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of s [...] (197 aa)
PON1Paraoxonase 1. (355 aa)
FAAHFatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. (579 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (557 aa)
CBR1Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). (289 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
CYP4F3Cytochrome P450 family 4 subfamily F member 3; Belongs to the cytochrome P450 family. (524 aa)
PLA2G4APhospholipase A2. (758 aa)
GGT5Gamma-glutamyltransferase 5. (639 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.