(8 nodes) EGFR Transactivation by Gastrin network (Sus scrofa)

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Your Input:
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	HBEGF	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GRB2	ENSSSCP00000068369	ENSSSCP00000018229	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.999
EGFR	HBEGF	ENSSSCP00000068369	ENSSSCP00000060087	Receptor protein-tyrosine kinase.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.996
EGFR	HRAS	ENSSSCP00000068369	ENSSSCP00000051149	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase.	0.976
EGFR	KRAS	ENSSSCP00000068369	ENSSSCP00000021836	Receptor protein-tyrosine kinase.	KRAS proto-oncogene, GTPase.	0.924
EGFR	NRAS	ENSSSCP00000068369	ENSSSCP00000046185	Receptor protein-tyrosine kinase.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.980
EGFR	PRKCA	ENSSSCP00000068369	ENSSSCP00000018296	Receptor protein-tyrosine kinase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.540
EGFR	SOS1	ENSSSCP00000068369	ENSSSCP00000009045	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
GRB2	EGFR	ENSSSCP00000018229	ENSSSCP00000068369	Growth factor receptor-bound protein 2 isoform 1.	Receptor protein-tyrosine kinase.	0.999
GRB2	HBEGF	ENSSSCP00000018229	ENSSSCP00000060087	Growth factor receptor-bound protein 2 isoform 1.	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	0.474
GRB2	HRAS	ENSSSCP00000018229	ENSSSCP00000051149	Growth factor receptor-bound protein 2 isoform 1.	HRas proto-oncogene, GTPase.	0.696
GRB2	KRAS	ENSSSCP00000018229	ENSSSCP00000021836	Growth factor receptor-bound protein 2 isoform 1.	KRAS proto-oncogene, GTPase.	0.704
GRB2	NRAS	ENSSSCP00000018229	ENSSSCP00000046185	Growth factor receptor-bound protein 2 isoform 1.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.705
GRB2	SOS1	ENSSSCP00000018229	ENSSSCP00000009045	Growth factor receptor-bound protein 2 isoform 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
HBEGF	EGFR	ENSSSCP00000060087	ENSSSCP00000068369	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	Receptor protein-tyrosine kinase.	0.996
HBEGF	GRB2	ENSSSCP00000060087	ENSSSCP00000018229	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	Growth factor receptor-bound protein 2 isoform 1.	0.474
HBEGF	HRAS	ENSSSCP00000060087	ENSSSCP00000051149	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	HRas proto-oncogene, GTPase.	0.517
HBEGF	KRAS	ENSSSCP00000060087	ENSSSCP00000021836	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	KRAS proto-oncogene, GTPase.	0.554
HBEGF	NRAS	ENSSSCP00000060087	ENSSSCP00000046185	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.517
HBEGF	SOS1	ENSSSCP00000060087	ENSSSCP00000009045	Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.403
HRAS	EGFR	ENSSSCP00000051149	ENSSSCP00000068369	HRas proto-oncogene, GTPase.	Receptor protein-tyrosine kinase.	0.976