STRINGSTRING
EXOC7 EXOC7 INHBE INHBE GNB3 GNB3 EXOC2 EXOC2 CES1-2 CES1-2 TSHB TSHB CTSZ CTSZ GNG13 GNG13 ERO1B ERO1B EXOC6 EXOC6 FFAR4 FFAR4 AOPEP AOPEP GHRL GHRL GPR119 GPR119 FSHB FSHB PCSK1 PCSK1 SPCS2 SPCS2 GNAT3 GNAT3 SPCS3 SPCS3 MBOAT4 MBOAT4 GCG GCG EXOC4 EXOC4 ACE ACE INHA INHA I3LDA9_PIG I3LDA9_PIG I3LP35_PIG I3LP35_PIG ACE2 ACE2 AGT AGT INHBC INHBC EXOC3 EXOC3 LHB-2 LHB-2 EXOC8 EXOC8 SLC30A8 SLC30A8 INS INS SLC30A5 SLC30A5 REN REN CGA CGA GNB1 GNB1 EXOC1 EXOC1 GH1 GH1 INHBA INHBA LOC100154047 LOC100154047 PLA2G7 PLA2G7 LEP LEP DPP4 DPP4 ATP6AP2 ATP6AP2 EXOC5 EXOC5 ENPEP ENPEP SEC11A SEC11A P4HB P4HB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (761 aa)
INHBEInhibin subunit beta E. (350 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (989 aa)
CES1-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (530 aa)
TSHBThyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (304 aa)
GNG13G protein subunit gamma 13. (67 aa)
ERO1BEndoplasmic reticulum oxidoreductase 1 beta. (507 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (823 aa)
FFAR4Free fatty acid receptor 4 isoform GPR120-S. (361 aa)
AOPEPAminopeptidase O (putative). (840 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
PCSK1P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (760 aa)
SPCS2Signal peptidase complex subunit 2. (287 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
SPCS3Signal peptidase complex subunit 3. (182 aa)
MBOAT4Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (433 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
EXOC4Exocyst complex component 4 tv1. (975 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (364 aa)
I3LDA9_PIGPeptidase S1 domain-containing protein. (236 aa)
I3LP35_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
INHBCInhibin beta C chain preproprotein. (354 aa)
EXOC3Exocyst complex component 3. (745 aa)
LHB-2Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (173 aa)
EXOC8Exocyst complex component 8. (727 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
SLC30A5Uncharacterized protein. (793 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (144 aa)
GNB1G protein subunit beta 1. (395 aa)
EXOC1Exocyst complex component 1. (927 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
LOC100154047Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (441 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
DPP4Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (353 aa)
EXOC5Exocyst complex component 5. (767 aa)
ENPEPGlutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family. (944 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
P4HBProtein disulfide-isomerase. (623 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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