(38 nodes) ECM proteoglycans network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPARC	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
	COL5A1	Fibrillar collagen NC1 domain-containing protein. (1918 aa)
	BCAN	Brevican core protein isoform X1. (906 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa)
	MATN3	Matrilin 3. (487 aa)
	DMP1	Dentin matrix acidic phosphoprotein 1. (531 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
	APP	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
	COL5A3	Collagen type V alpha 3 chain. (1747 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	VCAN	Versican. (3456 aa)
	COL1A2	Fibrillar collagen NC1 domain-containing protein. (1135 aa)
	FN1	Fibronectin 1. (2462 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
	MATN1	Matrilin 1. (496 aa)
	VTN	Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
	COL6A2	Collagen type VI alpha 2 chain. (943 aa)
	SERPINE1	Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
	COL6A3	Collagen type VI alpha 3 chain. (2911 aa)
	TNXB	Uncharacterized protein. (4137 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
	AGRN	Agrin. (2108 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
	COL9A3	Collagen type IX alpha 3 chain. (684 aa)
	DSPP	Uncharacterized protein. (1023 aa)
	NCAN	Neurocan. (1313 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (800 aa)
	COL6A5	Collagen type VI alpha 5 chain. (2337 aa)
	TNR	Tenascin R. (1270 aa)
	COL9A1	Collagen type IX alpha 1 chain. (922 aa)
	COL9A2	Uncharacterized protein. (709 aa)
	COL6A1	Collagen type VI alpha 1 chain. (1028 aa)
	COL1A1	Collagen type I alpha 1 chain. (1477 aa)
	COL6A6	Collagen type VI alpha 6 chain. (2266 aa)
	MATN4	Matrilin 4. (774 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (835 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRN	BCAN	ENSSSCP00000034280	ENSSSCP00000006902	Agrin.	Brevican core protein isoform X1.	0.681
AGRN	FN1	ENSSSCP00000034280	ENSSSCP00000017132	Agrin.	Fibronectin 1.	0.500
AGRN	NCAN	ENSSSCP00000034280	ENSSSCP00000048450	Agrin.	Neurocan.	0.532
AGRN	VCAN	ENSSSCP00000034280	ENSSSCP00000015031	Agrin.	Versican.	0.533
AGRN	VTN	ENSSSCP00000034280	ENSSSCP00000020670	Agrin.	Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).	0.520
APP	DMP1	ENSSSCP00000012805	ENSSSCP00000009831	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Dentin matrix acidic phosphoprotein 1.	0.520
APP	FN1	ENSSSCP00000012805	ENSSSCP00000017132	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Fibronectin 1.	0.548
APP	MATN3	ENSSSCP00000012805	ENSSSCP00000009174	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Matrilin 3.	0.475
APP	VCAN	ENSSSCP00000012805	ENSSSCP00000015031	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Versican.	0.449
BCAN	AGRN	ENSSSCP00000006902	ENSSSCP00000034280	Brevican core protein isoform X1.	Agrin.	0.681
BCAN	NCAN	ENSSSCP00000006902	ENSSSCP00000048450	Brevican core protein isoform X1.	Neurocan.	0.633
BCAN	TNR	ENSSSCP00000006902	ENSSSCP00000060729	Brevican core protein isoform X1.	Tenascin R.	0.626
BCAN	TNXB	ENSSSCP00000006902	ENSSSCP00000030534	Brevican core protein isoform X1.	Uncharacterized protein.	0.531
BCAN	VCAN	ENSSSCP00000006902	ENSSSCP00000015031	Brevican core protein isoform X1.	Versican.	0.650
COL1A1	COL1A2	ENSSSCP00000066291	ENSSSCP00000016253	Collagen type I alpha 1 chain.	Fibrillar collagen NC1 domain-containing protein.	0.999
COL1A1	COL2A1	ENSSSCP00000066291	ENSSSCP00000036099	Collagen type I alpha 1 chain.	Collagen type II alpha 1 chain.	0.751
COL1A1	COL5A1	ENSSSCP00000066291	ENSSSCP00000006161	Collagen type I alpha 1 chain.	Fibrillar collagen NC1 domain-containing protein.	0.859
COL1A1	COL5A3	ENSSSCP00000066291	ENSSSCP00000014530	Collagen type I alpha 1 chain.	Collagen type V alpha 3 chain.	0.612
COL1A1	COL6A1	ENSSSCP00000066291	ENSSSCP00000066198	Collagen type I alpha 1 chain.	Collagen type VI alpha 1 chain.	0.968
COL1A1	COL6A2	ENSSSCP00000066291	ENSSSCP00000026262	Collagen type I alpha 1 chain.	Collagen type VI alpha 2 chain.	0.923