(24 nodes) HDMs demethylate histones network (Sus scrofa)

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second shell of interactors

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Your Input:
	KDM5D	Lysine demethylase 5D. (1506 aa)
	JMJD6	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (413 aa)
	KDM4B	Lysine demethylase 4B. (1213 aa)
	KDM1B	Lysine demethylase 1B. (992 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
	PHF2	PHD finger protein 2. (1107 aa)
	KDM2B	Lysine demethylase 2B. (1312 aa)
	KDM5B	Lysine-specific demethylase 5B isoform 2. (1547 aa)
	ARID5B	AT-rich interaction domain 5B. (1194 aa)
	PHF8	PHD finger protein 8. (1060 aa)
	KDM3B	JmjC domain-containing protein. (759 aa)
	KDM7A	Lysine-specific demethylase 7A. (942 aa)
	LOC100621389	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	KDM4A	Uncharacterized protein. (1066 aa)
	KDM6A	Lysine demethylase 6A. (1400 aa)
	RIOX2	Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (464 aa)
	A0A286ZRB3_PIG	Histone domain-containing protein. (130 aa)
	KDM3A	Lysine demethylase 3A. (1323 aa)
	KDM4C	Lysine demethylase 4C. (1056 aa)
	A0A287AC28_PIG	Uncharacterized protein. (466 aa)
	KDM5A	Lysine-specific demethylase 5A. (1690 aa)
	HIST1H3E	Histone H3; Belongs to the histone H3 family. (136 aa)
	KDM2A	Lysine demethylase 2A. (1164 aa)
	KDM6B	Lysine demethylase 6B. (1638 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A286ZRB3_PIG	A0A287AC28_PIG	ENSSSCP00000034006	ENSSSCP00000041523	Histone domain-containing protein.	Uncharacterized protein.	0.527
A0A286ZRB3_PIG	ARID5B	ENSSSCP00000034006	ENSSSCP00000072713	Histone domain-containing protein.	AT-rich interaction domain 5B.	0.499
A0A286ZRB3_PIG	HIST1H3E	ENSSSCP00000034006	ENSSSCP00000053406	Histone domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.854
A0A286ZRB3_PIG	JMJD6	ENSSSCP00000034006	ENSSSCP00000060332	Histone domain-containing protein.	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase.	0.787
A0A286ZRB3_PIG	KDM1A	ENSSSCP00000034006	ENSSSCP00000003833	Histone domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.905
A0A286ZRB3_PIG	KDM1B	ENSSSCP00000034006	ENSSSCP00000001144	Histone domain-containing protein.	Lysine demethylase 1B.	0.597
A0A286ZRB3_PIG	KDM2A	ENSSSCP00000034006	ENSSSCP00000055554	Histone domain-containing protein.	Lysine demethylase 2A.	0.723
A0A286ZRB3_PIG	KDM2B	ENSSSCP00000034006	ENSSSCP00000010474	Histone domain-containing protein.	Lysine demethylase 2B.	0.770
A0A286ZRB3_PIG	KDM3A	ENSSSCP00000034006	ENSSSCP00000036454	Histone domain-containing protein.	Lysine demethylase 3A.	0.549
A0A286ZRB3_PIG	KDM3B	ENSSSCP00000034006	ENSSSCP00000015245	Histone domain-containing protein.	JmjC domain-containing protein.	0.484
A0A286ZRB3_PIG	KDM4A	ENSSSCP00000034006	ENSSSCP00000028143	Histone domain-containing protein.	Uncharacterized protein.	0.686
A0A286ZRB3_PIG	KDM4B	ENSSSCP00000034006	ENSSSCP00000058241	Histone domain-containing protein.	Lysine demethylase 4B.	0.671
A0A286ZRB3_PIG	KDM4C	ENSSSCP00000034006	ENSSSCP00000041258	Histone domain-containing protein.	Lysine demethylase 4C.	0.617
A0A286ZRB3_PIG	KDM5A	ENSSSCP00000034006	ENSSSCP00000052844	Histone domain-containing protein.	Lysine-specific demethylase 5A.	0.658
A0A286ZRB3_PIG	KDM5B	ENSSSCP00000034006	ENSSSCP00000011653	Histone domain-containing protein.	Lysine-specific demethylase 5B isoform 2.	0.603
A0A286ZRB3_PIG	KDM5D	ENSSSCP00000034006	ENSSSCP00000072411	Histone domain-containing protein.	Lysine demethylase 5D.	0.617
A0A286ZRB3_PIG	KDM6A	ENSSSCP00000034006	ENSSSCP00000030254	Histone domain-containing protein.	Lysine demethylase 6A.	0.860
A0A286ZRB3_PIG	KDM6B	ENSSSCP00000034006	ENSSSCP00000056765	Histone domain-containing protein.	Lysine demethylase 6B.	0.902
A0A286ZRB3_PIG	KDM7A	ENSSSCP00000034006	ENSSSCP00000017483	Histone domain-containing protein.	Lysine-specific demethylase 7A.	0.605
A0A286ZRB3_PIG	LOC100621389	ENSSSCP00000034006	ENSSSCP00000027849	Histone domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.921