(58 nodes) Regulation of HSF1-mediated heat shock response network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ST13	ST13 Hsp70 interacting protein. (374 aa)
	HSPA12B	Heat shock protein family A (Hsp70) member 12B. (703 aa)
	NUP54	Nucleoporin 54. (564 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
	BAG3	BCL2 associated athanogene 3. (609 aa)
	NUP210	Nucleoporin 210. (1946 aa)
	HSPA13	Heat shock protein family A (Hsp70) member 13. (464 aa)
	NUP160	Nucleoporin 160. (1437 aa)
	DNAJB1	J domain-containing protein. (339 aa)
	NUP98	Nucleoporin 98. (1753 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
	F1SRM6_PIG	Uncharacterized protein. (954 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (684 aa)
	HSPA1L	Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (641 aa)
	NUP205	Nucleoporin 205. (2026 aa)
	RPA3	Replication protein A3. (121 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RANBP2	RAN binding protein 2. (3233 aa)
	HIKESHI	Heat shock protein nuclear import factor hikeshi. (197 aa)
	RAE1	mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. (368 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2518 aa)
	NUP88	Nucleoporin 88. (739 aa)
	NUP214	Nucleoporin 214. (2016 aa)
	HSF1	Heat shock transcription factor 1. (590 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (680 aa)
	NUP155	Nucleoporin 155. (1391 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (797 aa)
	POM121C	Uncharacterized protein. (1193 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
	NUP133	Nucleoporin 133. (1160 aa)
	BAG4	BAG family molecular chaperone regulator 4 isoform 1. (457 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
	BAG2	BCL2 associated athanogene 2. (210 aa)
	NUP62	Nucleoporin 62. (478 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (848 aa)
	NUP37	Nucleoporin Nup37. (333 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	NUP43	Nucleoporin Nup43 isoform X2. (380 aa)
	HSPA12A	Heat shock protein family A (Hsp70) member 12A. (702 aa)
	NUP188	Nucleoporin 188. (1769 aa)
	A0A287BQU9_PIG	Uncharacterized protein. (923 aa)
	BAG5	BAG family molecular chaperone regulator 5 isoform b. (447 aa)
	NUP107	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
	NUP42	Nucleoporin-like protein 2. (418 aa)
	NUP153	Nucleoporin 153. (1473 aa)
	DNAJB6	DnaJ heat shock protein family (Hsp40) member B6. (330 aa)
	AAAS	Aladin WD repeat nucleoporin. (554 aa)
	NUP35	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (327 aa)
	NDC1	NDC1 transmembrane nucleoporin. (757 aa)
	HSPH1	Heat shock protein family H (Hsp110) member 1. (861 aa)
	NPAP1	Uncharacterized protein. (1181 aa)
	DNAJC2	DnaJ heat shock protein family (Hsp40) member C2. (621 aa)
	HSPA14	Heat shock protein family A (Hsp70) member 14; Belongs to the heat shock protein 70 family. (509 aa)
	BAG1	BCL2 associated athanogene 1. (322 aa)
	RPA2	RPA_C domain-containing protein. (270 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (341 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
	NUP58	Nucleoporin 58. (583 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287BQU9_PIG	AAAS	ENSSSCP00000058891	ENSSSCP00000064695	Uncharacterized protein.	Aladin WD repeat nucleoporin.	0.400
A0A287BQU9_PIG	BAG1	ENSSSCP00000058891	ENSSSCP00000072040	Uncharacterized protein.	BCL2 associated athanogene 1.	0.445
A0A287BQU9_PIG	BAG2	ENSSSCP00000058891	ENSSSCP00000048016	Uncharacterized protein.	BCL2 associated athanogene 2.	0.913
A0A287BQU9_PIG	BAG3	ENSSSCP00000058891	ENSSSCP00000011385	Uncharacterized protein.	BCL2 associated athanogene 3.	0.965
A0A287BQU9_PIG	BAG4	ENSSSCP00000058891	ENSSSCP00000045648	Uncharacterized protein.	BAG family molecular chaperone regulator 4 isoform 1.	0.642
A0A287BQU9_PIG	BAG5	ENSSSCP00000058891	ENSSSCP00000059201	Uncharacterized protein.	BAG family molecular chaperone regulator 5 isoform b.	0.677
A0A287BQU9_PIG	DNAJB1	ENSSSCP00000058891	ENSSSCP00000014656	Uncharacterized protein.	J domain-containing protein.	0.924
A0A287BQU9_PIG	DNAJB6	ENSSSCP00000058891	ENSSSCP00000064172	Uncharacterized protein.	DnaJ heat shock protein family (Hsp40) member B6.	0.883
A0A287BQU9_PIG	DNAJC2	ENSSSCP00000058891	ENSSSCP00000066258	Uncharacterized protein.	DnaJ heat shock protein family (Hsp40) member C2.	0.836
A0A287BQU9_PIG	F1SRM6_PIG	ENSSSCP00000058891	ENSSSCP00000017784	Uncharacterized protein.	Uncharacterized protein.	0.438
A0A287BQU9_PIG	HIKESHI	ENSSSCP00000058891	ENSSSCP00000025601	Uncharacterized protein.	Heat shock protein nuclear import factor hikeshi.	0.591
A0A287BQU9_PIG	HSF1	ENSSSCP00000058891	ENSSSCP00000034486	Uncharacterized protein.	Heat shock transcription factor 1.	0.859
A0A287BQU9_PIG	HSPA12A	ENSSSCP00000058891	ENSSSCP00000057824	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 12A.	0.611
A0A287BQU9_PIG	HSPA12B	ENSSSCP00000058891	ENSSSCP00000007610	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 12B.	0.604
A0A287BQU9_PIG	HSPA13	ENSSSCP00000058891	ENSSSCP00000012792	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 13.	0.536
A0A287BQU9_PIG	HSPA14	ENSSSCP00000058891	ENSSSCP00000071129	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 14; Belongs to the heat shock protein 70 family.	0.559
A0A287BQU9_PIG	HSPA1L	ENSSSCP00000058891	ENSSSCP00000020097	Uncharacterized protein.	Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...]	0.406
A0A287BQU9_PIG	HSPA4	ENSSSCP00000058891	ENSSSCP00000052080	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 4.	0.799
A0A287BQU9_PIG	HSPA8	ENSSSCP00000058891	ENSSSCP00000036002	Uncharacterized protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.799
A0A287BQU9_PIG	HSPA9	ENSSSCP00000058891	ENSSSCP00000041902	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.	0.690