(19 nodes) Integrin signaling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	CSK	Tyrosine-protein kinase. (474 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (995 aa)
	FN1	Fibronectin 1. (2462 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (835 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3 isoform a. (923 aa)
	FGG	Fibrinogen gamma chain. (454 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	CRK	CRK proto-oncogene, adaptor protein. (385 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein. (688 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	TLN1	Talin 1. (2558 aa)
	RASGRP2	Uncharacterized protein. (881 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (887 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1IP	BCAR1	ENSSSCP00000035740	ENSSSCP00000050049	Amyloid beta precursor protein binding family B member 1 interacting protein.	BCAR1 scaffold protein, Cas family member.	0.532
APBB1IP	CRK	ENSSSCP00000035740	ENSSSCP00000034913	Amyloid beta precursor protein binding family B member 1 interacting protein.	CRK proto-oncogene, adaptor protein.	0.613
APBB1IP	CSK	ENSSSCP00000035740	ENSSSCP00000002078	Amyloid beta precursor protein binding family B member 1 interacting protein.	Tyrosine-protein kinase.	0.505
APBB1IP	FGG	ENSSSCP00000035740	ENSSSCP00000024374	Amyloid beta precursor protein binding family B member 1 interacting protein.	Fibrinogen gamma chain.	0.400
APBB1IP	FN1	ENSSSCP00000035740	ENSSSCP00000017132	Amyloid beta precursor protein binding family B member 1 interacting protein.	Fibronectin 1.	0.426
APBB1IP	GRB2	ENSSSCP00000035740	ENSSSCP00000018229	Amyloid beta precursor protein binding family B member 1 interacting protein.	Growth factor receptor-bound protein 2 isoform 1.	0.635
APBB1IP	ITGB3	ENSSSCP00000035740	ENSSSCP00000072331	Amyloid beta precursor protein binding family B member 1 interacting protein.	Integrin beta; Belongs to the integrin beta chain family.	0.457
APBB1IP	PTPN1	ENSSSCP00000035740	ENSSSCP00000037956	Amyloid beta precursor protein binding family B member 1 interacting protein.	Tyrosine-protein phosphatase non-receptor type.	0.540
APBB1IP	RAP1A	ENSSSCP00000035740	ENSSSCP00000050852	Amyloid beta precursor protein binding family B member 1 interacting protein.	RAP1A, member of RAS oncogene family.	0.957
APBB1IP	RAP1B	ENSSSCP00000035740	ENSSSCP00000035670	Amyloid beta precursor protein binding family B member 1 interacting protein.	RAP1B, member of RAS oncogene family.	0.957
APBB1IP	RAPGEF3	ENSSSCP00000035740	ENSSSCP00000020148	Amyloid beta precursor protein binding family B member 1 interacting protein.	Rap guanine nucleotide exchange factor 3 isoform a.	0.479
APBB1IP	SHC1	ENSSSCP00000035740	ENSSSCP00000028571	Amyloid beta precursor protein binding family B member 1 interacting protein.	SHC adaptor protein 1.	0.559
APBB1IP	SOS1	ENSSSCP00000035740	ENSSSCP00000009045	Amyloid beta precursor protein binding family B member 1 interacting protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.524
APBB1IP	SRC	ENSSSCP00000035740	ENSSSCP00000029882	Amyloid beta precursor protein binding family B member 1 interacting protein.	Tyrosine-protein kinase.	0.498
APBB1IP	TLN1	ENSSSCP00000035740	ENSSSCP00000041366	Amyloid beta precursor protein binding family B member 1 interacting protein.	Talin 1.	0.961
BCAR1	APBB1IP	ENSSSCP00000050049	ENSSSCP00000035740	BCAR1 scaffold protein, Cas family member.	Amyloid beta precursor protein binding family B member 1 interacting protein.	0.532
BCAR1	CRK	ENSSSCP00000050049	ENSSSCP00000034913	BCAR1 scaffold protein, Cas family member.	CRK proto-oncogene, adaptor protein.	0.994
BCAR1	FGG	ENSSSCP00000050049	ENSSSCP00000024374	BCAR1 scaffold protein, Cas family member.	Fibrinogen gamma chain.	0.499
BCAR1	FN1	ENSSSCP00000050049	ENSSSCP00000017132	BCAR1 scaffold protein, Cas family member.	Fibronectin 1.	0.583
BCAR1	GRB2	ENSSSCP00000050049	ENSSSCP00000018229	BCAR1 scaffold protein, Cas family member.	Growth factor receptor-bound protein 2 isoform 1.	0.583