(8 nodes) Negative regulation of TCF-dependent signaling by WNT ligand antagonists network (Sus scrofa)

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Your Input:
	SOST	Sclerostin. (212 aa)
	DKK4	Dickkopf WNT signaling pathway inhibitor 4. (223 aa)
	KREMEN1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa)
	DKK1	Dickkopf_N domain-containing protein. (357 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
	KREMEN2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKK1	DKK2	ENSSSCP00000011117	ENSSSCP00000045342	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 2.	0.959
DKK1	DKK4	ENSSSCP00000011117	ENSSSCP00000007491	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 4.	0.950
DKK1	KREMEN1	ENSSSCP00000011117	ENSSSCP00000010643	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.951
DKK1	KREMEN2	ENSSSCP00000011117	ENSSSCP00000045879	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.915
DKK1	LRP5	ENSSSCP00000011117	ENSSSCP00000013700	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.999
DKK1	LRP6	ENSSSCP00000011117	ENSSSCP00000040912	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.999
DKK1	SOST	ENSSSCP00000011117	ENSSSCP00000045765	Dickkopf_N domain-containing protein.	Sclerostin.	0.781
DKK2	DKK1	ENSSSCP00000045342	ENSSSCP00000011117	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf_N domain-containing protein.	0.959
DKK2	DKK4	ENSSSCP00000045342	ENSSSCP00000007491	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 4.	0.905
DKK2	KREMEN1	ENSSSCP00000045342	ENSSSCP00000010643	Dickkopf WNT signaling pathway inhibitor 2.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.852
DKK2	KREMEN2	ENSSSCP00000045342	ENSSSCP00000045879	Dickkopf WNT signaling pathway inhibitor 2.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.743
DKK2	LRP5	ENSSSCP00000045342	ENSSSCP00000013700	Dickkopf WNT signaling pathway inhibitor 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.990
DKK2	LRP6	ENSSSCP00000045342	ENSSSCP00000040912	Dickkopf WNT signaling pathway inhibitor 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.992
DKK2	SOST	ENSSSCP00000045342	ENSSSCP00000045765	Dickkopf WNT signaling pathway inhibitor 2.	Sclerostin.	0.569
DKK4	DKK1	ENSSSCP00000007491	ENSSSCP00000011117	Dickkopf WNT signaling pathway inhibitor 4.	Dickkopf_N domain-containing protein.	0.950
DKK4	DKK2	ENSSSCP00000007491	ENSSSCP00000045342	Dickkopf WNT signaling pathway inhibitor 4.	Dickkopf WNT signaling pathway inhibitor 2.	0.905
DKK4	KREMEN1	ENSSSCP00000007491	ENSSSCP00000010643	Dickkopf WNT signaling pathway inhibitor 4.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.851
DKK4	KREMEN2	ENSSSCP00000007491	ENSSSCP00000045879	Dickkopf WNT signaling pathway inhibitor 4.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.771
DKK4	LRP5	ENSSSCP00000007491	ENSSSCP00000013700	Dickkopf WNT signaling pathway inhibitor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.987
DKK4	LRP6	ENSSSCP00000007491	ENSSSCP00000040912	Dickkopf WNT signaling pathway inhibitor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.980