STRINGSTRING
PDPK1 PDPK1 HLA-DRA HLA-DRA CSK CSK FYN FYN CD274 CD274 LYN LYN PAK2 PAK2 CD80 CD80 PPP2R5B PPP2R5B PPP2CA PPP2CA PPP2R5A PPP2R5A GRB2 GRB2 MAP3K14 MAP3K14 CD4 CD4 I3LAQ5_PIG I3LAQ5_PIG PIK3R1 PIK3R1 ICOS ICOS MAP3K8 MAP3K8 CD86 CD86 CD3D CD3D CDC42 CDC42 SRC SRC PAK1 PAK1 A0A286ZKB7_PIG A0A286ZKB7_PIG VAV1 VAV1 PTPN6 PTPN6 PDCD1 PDCD1 GRAP2 GRAP2 A0A287AAB9_PIG A0A287AAB9_PIG A0A287AC24_PIG A0A287AC24_PIG CD3G CD3G LCK LCK A0A287ARF7_PIG A0A287ARF7_PIG A0A287AT33_PIG A0A287AT33_PIG LOC102158035 LOC102158035 PPP2R5E PPP2R5E PIK3CA PIK3CA LOC100511937 LOC100511937 SLA-DRB1 SLA-DRB1 PPP2R5D PPP2R5D A0A287BPL5_PIG A0A287BPL5_PIG A0A287BQ00_PIG A0A287BQ00_PIG A0A287BQ31_PIG A0A287BQ31_PIG PIK3R2 PIK3R2 YES1 YES1 RAC1 RAC1 PDCD1LG2 PDCD1LG2 PTPN11 PTPN11 ICOSLG ICOSLG PPP2R5C PPP2R5C SLA-DQA1 SLA-DQA1 CD28 CD28 PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa)
CSKTyrosine-protein kinase. (474 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
CD274CD274 molecule. (311 aa)
LYNTyrosine-protein kinase. (512 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CD80CD80 molecule. (297 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (930 aa)
CD4CD4 molecule. (494 aa)
I3LAQ5_PIGIg-like domain-containing protein. (164 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
ICOSIGv domain-containing protein. (209 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (496 aa)
CD86T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
CD3DT-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
SRCTyrosine-protein kinase. (559 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
A0A286ZKB7_PIGIg-like domain-containing protein. (259 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
PDCD1Programmed cell death 1. (287 aa)
GRAP2GRB2-related adapter protein 2 isoform 1. (320 aa)
A0A287AAB9_PIGIg-like domain-containing protein. (252 aa)
A0A287AC24_PIGIg-like domain-containing protein. (112 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
LCKTyrosine-protein kinase. (520 aa)
A0A287ARF7_PIGIg-like domain-containing protein. (139 aa)
A0A287AT33_PIGIg-like domain-containing protein. (173 aa)
LOC102158035Ig-like domain-containing protein. (268 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (477 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
SLA-DRB1Ig-like domain-containing protein. (307 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (614 aa)
A0A287BPL5_PIGIg-like domain-containing protein. (154 aa)
A0A287BQ00_PIGIg-like domain-containing protein. (194 aa)
A0A287BQ31_PIGIg-like domain-containing protein. (180 aa)
PIK3R2Uncharacterized protein. (772 aa)
YES1Tyrosine-protein kinase. (553 aa)
RAC1Rac family small GTPase 1. (186 aa)
PDCD1LG2IG domain-containing protein. (290 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ICOSLGIg-like domain-containing protein. (483 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (659 aa)
SLA-DQA1SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa)
CD28IGv domain-containing protein. (222 aa)
PPP2CBSerine/threonine-protein phosphatase. (476 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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