(11 nodes) CD28 dependent Vav1 pathway network (Sus scrofa)

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Your Input:
	FYN	Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
	CD28	IGv domain-containing protein. (222 aa)
	RAC1	Rac family small GTPase 1. (186 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	CD86	T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	CD80	CD80 molecule. (297 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	CD80	ENSSSCP00000071532	ENSSSCP00000012679	IGv domain-containing protein.	CD80 molecule.	0.996
CD28	CD86	ENSSSCP00000071532	ENSSSCP00000028828	IGv domain-containing protein.	T-lymphocyte activation antigen CD86 isoform 1.	0.997
CD28	CDC42	ENSSSCP00000071532	ENSSSCP00000029815	IGv domain-containing protein.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.544
CD28	FYN	ENSSSCP00000071532	ENSSSCP00000004770	IGv domain-containing protein.	Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...]	0.628
CD28	GRB2	ENSSSCP00000071532	ENSSSCP00000018229	IGv domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.970
CD28	LCK	ENSSSCP00000071532	ENSSSCP00000043318	IGv domain-containing protein.	Tyrosine-protein kinase.	0.727
CD28	PAK1	ENSSSCP00000071532	ENSSSCP00000030505	IGv domain-containing protein.	Non-specific serine/threonine protein kinase.	0.526
CD28	PAK2	ENSSSCP00000071532	ENSSSCP00000012614	IGv domain-containing protein.	Non-specific serine/threonine protein kinase.	0.556
CD28	RAC1	ENSSSCP00000071532	ENSSSCP00000062132	IGv domain-containing protein.	Rac family small GTPase 1.	0.541
CD28	VAV1	ENSSSCP00000071532	ENSSSCP00000033977	IGv domain-containing protein.	Vav guanine nucleotide exchange factor 1.	0.643
CD80	CD28	ENSSSCP00000012679	ENSSSCP00000071532	CD80 molecule.	IGv domain-containing protein.	0.996
CD80	CD86	ENSSSCP00000012679	ENSSSCP00000028828	CD80 molecule.	T-lymphocyte activation antigen CD86 isoform 1.	0.991
CD80	CDC42	ENSSSCP00000012679	ENSSSCP00000029815	CD80 molecule.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.554
CD80	FYN	ENSSSCP00000012679	ENSSSCP00000004770	CD80 molecule.	Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...]	0.600
CD80	GRB2	ENSSSCP00000012679	ENSSSCP00000018229	CD80 molecule.	Growth factor receptor-bound protein 2 isoform 1.	0.563
CD80	LCK	ENSSSCP00000012679	ENSSSCP00000043318	CD80 molecule.	Tyrosine-protein kinase.	0.665
CD80	PAK1	ENSSSCP00000012679	ENSSSCP00000030505	CD80 molecule.	Non-specific serine/threonine protein kinase.	0.499
CD80	PAK2	ENSSSCP00000012679	ENSSSCP00000012614	CD80 molecule.	Non-specific serine/threonine protein kinase.	0.499
CD80	RAC1	ENSSSCP00000012679	ENSSSCP00000062132	CD80 molecule.	Rac family small GTPase 1.	0.564
CD80	VAV1	ENSSSCP00000012679	ENSSSCP00000033977	CD80 molecule.	Vav guanine nucleotide exchange factor 1.	0.524