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| | DAGLA | Diacylglycerol lipase alpha. (1058 aa) |
| | NPFF | Neuropeptide FF-amide peptide precursor. (114 aa) |
| | TAC3 | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. (126 aa) |
| | ARHGEF25 | Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa) |
| | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa) |
| | PMCH | Pro-MCH preproprotein. (165 aa) |
| | NTS | Neurotensin/neuromedin N preproprotein. (171 aa) |
| | HCRTR2 | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. (444 aa) |
| | FFAR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (566 aa) |
| | LPAR3 | Lysophosphatidic acid receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (354 aa) |
| | RGS17 | Regulator of G-protein signaling 17. (210 aa) |
| | MCHR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | PRKCH | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa) |
| | QRFP | Pyroglutamylated RFamide peptide. (134 aa) |
| | XCL1 | Lymphotactin isoform X1. (110 aa) |
| | RGS4 | Regulator of G protein signaling 4. (205 aa) |
| | GNRHR2 | Gonadotropin-releasing hormone receptor isoform 1. (293 aa) |
| | PROK1 | Prokineticin 1. (105 aa) |
| | ADRA1D | Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. (570 aa) |
| | AVP | Vasopressin-neurophysin 2-copeptin. (217 aa) |
| | OXT | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (125 aa) |
| | GNB2 | G protein subunit beta 2. (340 aa) |
| | GNG13 | G protein subunit gamma 13. (67 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | NTSR2 | Neurotensin receptor 2; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | NPFFR2 | Neuropeptide FF receptor 2; Belongs to the G-protein coupled receptor 1 family. (418 aa) |
| | TRPC3 | Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa) |
| | QRFPR | Pyroglutamylated RFamide peptide receptor; Belongs to the G-protein coupled receptor 1 family. (431 aa) |
| | EDNRB | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa) |
| | GNRH1 | GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. (91 aa) |
| | TACR2 | Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (404 aa) |
| | NPFFR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (432 aa) |
| | FFAR4 | Free fatty acid receptor 4 isoform GPR120-S. (361 aa) |
| | NPS | Neuropeptide S. (89 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa) |
| | CCK | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (154 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa) |
| | TRH | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (241 aa) |
| | P2RY1 | Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (371 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
| | GPR143 | Uncharacterized protein. (405 aa) |
| | GRPR | Gastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (395 aa) |
| | DGKK | Diacylglycerol kinase. (1266 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa) |
| | NMUR1 | Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (556 aa) |
| | LTB4R2 | Leukotriene B4 receptor 2. (358 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | RGS5 | Regulator of G-protein signaling 5; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). (206 aa) |
| | GRK2 | G protein-coupled receptor kinase 2. (778 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | TRPC6 | Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (939 aa) |
| | KISS1R | G protein-coupled receptor 54. (399 aa) |
| | GNA15 | Guanine nucleotide-binding protein subunit alpha-15. (374 aa) |
| | PTGER1 | Prostaglandin E receptor 1. (405 aa) |
| | F2RL1 | Proteinase-activated receptor 2 preproprotein. (397 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa) |
| | RGSL1 | Regulator of G protein signaling like 1. (1087 aa) |
| | AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa) |
| | GCG | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa) |
| | DGKD | Diacylglycerol kinase. (1244 aa) |
| | NPSR1 | Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (369 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3109 aa) |
| | ADRA1B | Adrenoceptor alpha 1B. (518 aa) |
| | NMUR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (410 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) |
| | HCRT | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). (131 aa) |
| | DGKE | Diacylglycerol kinase. (566 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | LTB4R | Leukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | CCKAR | Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa) |
| | ABHD12 | Monoacylglycerol lipase ABHD12 isoform a. (396 aa) |
| | P2RY11 | PPAN-P2RY11 protein isoform 1; Belongs to the G-protein coupled receptor 1 family. (377 aa) |
| | MLNR | Motilin receptor; Belongs to the G-protein coupled receptor 1 family. (406 aa) |
| | PROK2 | Prokineticin 2. (129 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (248 aa) |
| | DGKG | Diacylglycerol kinase. (791 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | XCR1 | Chemokine XC receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | GRM5 | Glutamate metabotropic receptor 5. (1212 aa) |
| | P2RY10 | P2Y receptor family member 10. (328 aa) |
| | F2RL3 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | LPAR4 | Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (482 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | HTR2C | 5-hydroxytryptamine receptor 2C. (457 aa) |
| | GPR68 | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | GNB5 | G protein subunit beta 5. (420 aa) |
| | PROKR2 | Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | RGS1 | Regulator of G-protein signaling 1. (209 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (240 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | RGS21 | Regulator of G protein signaling 21. (152 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa) |
| | HRH1 | Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (506 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | MGLL | Monoglyceride lipase. (456 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (759 aa) |
| | RGS18 | Regulator of G-protein signaling 18. (235 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa) |
| | LPAR2 | Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | LOC100516039 | C-C motif chemokine. (243 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
| | GPR143-2 | Uncharacterized protein. (412 aa) |
| | RGS2 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] (212 aa) |
| | TBXA2R | Thromboxane A2 receptor. (343 aa) |
| | DGKZ | Diacylglycerol kinase. (1144 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | TAC1 | Tachykinin precursor 1. (130 aa) |
| | EDN2 | Endothelin 2. (180 aa) |
| | ABHD6 | Abhydrolase domain containing 6. (337 aa) |
| | CASR | Extracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as [...] (1089 aa) |
| | LPAR5 | Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | A0A287ACS9_PIG | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa) |
| | LOC110255211 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa) |
| | DGKI | Diacylglycerol kinase. (1110 aa) |
| | P2RY2 | P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP > ATP. (373 aa) |
| | DGKA | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (856 aa) |
| | GNA14 | Guanine nucleotide-binding protein alpha 14. (355 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (840 aa) |
| | CHRM3 | Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (590 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | PTGFR | Prostaglandin F2-alpha receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | TRHR | Thyrotropin-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (398 aa) |
| | ADRA1A | Alpha-1A adrenergic receptor isoform 1. (466 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1195 aa) |
| | DGKH | Diacylglycerol kinase. (1222 aa) |
| | RGS13 | Regulator of G protein signaling 13. (182 aa) |
| | LPAR1 | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | GNB1 | G protein subunit beta 1. (395 aa) |
| | GNRH2 | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (119 aa) |
| | UTS2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) |
| | F2RL2 | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | GPR132 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (430 aa) |
| | RGS19 | Regulator of G protein signaling 19. (302 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | DGKB | Diacylglycerol kinase. (802 aa) |
| | PROKR1 | Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa) |
| | CHRM5 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (508 aa) |
| | BRS3 | Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | NTSR1 | Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (417 aa) |
| | UTS2B | Urotensin 2B. (119 aa) |
| | DAGLB | Diacylglycerol lipase beta. (691 aa) |
| | GPR17 | G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | P2RY6 | Pyrimidinergic receptor P2Y6. (515 aa) |
| | KISS1 | KiSS-1 metastasis-suppressor. (138 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa) |
| | NMBR | Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa) |
| | TACR3 | Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (463 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | OPN4 | Opsin 4. (488 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | UBA6 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. (1396 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | DGKQ | Diacylglycerol kinase. (987 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa) |
| | RGS16 | Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. (274 aa) |
| | RGS3 | Regulator of G protein signaling 3. (913 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa) |
| | TRPC7 | Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (862 aa) |
| | EDN3 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | KNG1 | Kininogen 1. (630 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (744 aa) |
| | LOC100621431 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (234 aa) |
| | GCGR | G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa) |
