71 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VAV2	Vav guanine nucleotide exchange factor 2. (879 aa)
	ARHGEF25	Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa)
	GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
	AKAP13	Uncharacterized protein. (1420 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1704 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	RHOC	Ras homolog family member C. (202 aa)
	ADRA1D	Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. (570 aa)
	GNB2	G protein subunit beta 2. (340 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	PLXNB1	Plexin B1. (2133 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1611 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (960 aa)
	ARHGEF17	DH domain-containing protein. (1043 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3109 aa)
	ADRA1B	Adrenoceptor alpha 1B. (518 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (569 aa)
	FGD3	FYVE, RhoGEF and PH domain-containing protein 3 isoform X1. (735 aa)
	PLEKHG2	Pleckstrin homology and RhoGEF domain containing G2. (1357 aa)
	ARHGEF38	Rho guanine nucleotide exchange factor 38. (778 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (248 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (844 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1574 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	ECT2	Epithelial cell transforming 2. (1028 aa)
	GNB5	G protein subunit beta 5. (420 aa)
	ARHGEF9	Uncharacterized protein. (1109 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1172 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (240 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	FGD2	FYVE, RhoGEF and PH domain containing 2. (656 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (711 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1270 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	TBXA2R	Thromboxane A2 receptor. (343 aa)
	ARHGEF18	Rho guanine nucleotide exchange factor 18 isoform X3. (1346 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	A0A287ACS9_PIG	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
	LOC110255211	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	GNA12	G protein subunit alpha 12. (382 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (1181 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (766 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (872 aa)
	ADRA1A	Alpha-1A adrenergic receptor isoform 1. (466 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (823 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	GNB1	G protein subunit beta 1. (395 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19 isoform X1. (879 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1298 aa)
	NET1	Neuroepithelial cell transforming 1. (574 aa)
	FGD4	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1415 aa)
	ARHGEF33	Rho guanine nucleotide exchange factor 33. (868 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1274 aa)
	ABR	ABR activator of RhoGEF and GTPase. (964 aa)
	ROCK2	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor 39. (370 aa)
	ITSN1	Intersectin 1. (1485 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (874 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1577 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)
	LOC100621431	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (234 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ACS9_PIG	ADRA1A	ENSSSCP00000041693	ENSSSCP00000047540	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Alpha-1A adrenergic receptor isoform 1.	0.538
A0A287ACS9_PIG	ADRA1B	ENSSSCP00000041693	ENSSSCP00000018054	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adrenoceptor alpha 1B.	0.538
A0A287ACS9_PIG	ADRA1D	ENSSSCP00000041693	ENSSSCP00000007601	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.	0.538
A0A287ACS9_PIG	ARHGEF1	ENSSSCP00000041693	ENSSSCP00000044252	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Rho guanine nucleotide exchange factor 1.	0.530
A0A287ACS9_PIG	ARHGEF12	ENSSSCP00000041693	ENSSSCP00000047751	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Rho guanine nucleotide exchange factor 12.	0.701
A0A287ACS9_PIG	ARHGEF25	ENSSSCP00000041693	ENSSSCP00000000469	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Rho guanine nucleotide exchange factor 25 isoform X1.	0.499
A0A287ACS9_PIG	ARHGEF6	ENSSSCP00000041693	ENSSSCP00000043202	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.499
A0A287ACS9_PIG	BTK	ENSSSCP00000041693	ENSSSCP00000025530	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Tyrosine-protein kinase.	0.501
A0A287ACS9_PIG	GNA12	ENSSSCP00000041693	ENSSSCP00000043999	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit alpha 12.	0.811
A0A287ACS9_PIG	GNA13	ENSSSCP00000041693	ENSSSCP00000040165	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit alpha 13.	0.690
A0A287ACS9_PIG	GNB1	ENSSSCP00000041693	ENSSSCP00000048402	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 1.	0.805
A0A287ACS9_PIG	GNB2	ENSSSCP00000041693	ENSSSCP00000008190	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 2.	0.865
A0A287ACS9_PIG	GNB3	ENSSSCP00000041693	ENSSSCP00000000727	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.	0.984
A0A287ACS9_PIG	GNB4	ENSSSCP00000041693	ENSSSCP00000036910	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 4.	0.851
A0A287ACS9_PIG	GNB5	ENSSSCP00000041693	ENSSSCP00000031679	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 5.	0.987
A0A287ACS9_PIG	GNG10	ENSSSCP00000041693	ENSSSCP00000072165	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.439
A0A287ACS9_PIG	GNG13	ENSSSCP00000041693	ENSSSCP00000008555	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit gamma 13.	0.629
A0A287ACS9_PIG	GNG2	ENSSSCP00000041693	ENSSSCP00000024099	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.540
A0A287ACS9_PIG	GNG3	ENSSSCP00000041693	ENSSSCP00000032340	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.400
A0A287ACS9_PIG	GNG8	ENSSSCP00000041693	ENSSSCP00000025202	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.540