(8 nodes) Sema4D mediated inhibition of cell attachment and migration network (Sus scrofa)

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Your Input:
	RND1	Rho family GTPase 1. (244 aa)
	RAC1	Rac family small GTPase 1. (186 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	RRAS	RAS related. (218 aa)
	PLXNB1	Plexin B1. (2133 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
	SEMA4D	Semaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	MET	ENSSSCP00000003363	ENSSSCP00000017620	Rho GTPase-activating protein 35.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.540
ARHGAP35	PLXNB1	ENSSSCP00000003363	ENSSSCP00000012099	Rho GTPase-activating protein 35.	Plexin B1.	0.532
ARHGAP35	RAC1	ENSSSCP00000003363	ENSSSCP00000062132	Rho GTPase-activating protein 35.	Rac family small GTPase 1.	0.515
ARHGAP35	RHOA	ENSSSCP00000003363	ENSSSCP00000045785	Rho GTPase-activating protein 35.	Transforming protein RhoA isoform 1.	0.962
ARHGAP35	RND1	ENSSSCP00000003363	ENSSSCP00000059270	Rho GTPase-activating protein 35.	Rho family GTPase 1.	0.795
ARHGAP35	SEMA4D	ENSSSCP00000003363	ENSSSCP00000029503	Rho GTPase-activating protein 35.	Semaphorin-4D isoform X1; Belongs to the semaphorin family.	0.529
MET	ARHGAP35	ENSSSCP00000017620	ENSSSCP00000003363	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Rho GTPase-activating protein 35.	0.540
MET	PLXNB1	ENSSSCP00000017620	ENSSSCP00000012099	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B1.	0.932
MET	RAC1	ENSSSCP00000017620	ENSSSCP00000062132	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Rac family small GTPase 1.	0.655
MET	RHOA	ENSSSCP00000017620	ENSSSCP00000045785	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Transforming protein RhoA isoform 1.	0.698
MET	RND1	ENSSSCP00000017620	ENSSSCP00000059270	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Rho family GTPase 1.	0.674
MET	RRAS	ENSSSCP00000017620	ENSSSCP00000003452	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	RAS related.	0.660
MET	SEMA4D	ENSSSCP00000017620	ENSSSCP00000029503	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Semaphorin-4D isoform X1; Belongs to the semaphorin family.	0.711
PLXNB1	ARHGAP35	ENSSSCP00000012099	ENSSSCP00000003363	Plexin B1.	Rho GTPase-activating protein 35.	0.532
PLXNB1	MET	ENSSSCP00000012099	ENSSSCP00000017620	Plexin B1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.932
PLXNB1	RAC1	ENSSSCP00000012099	ENSSSCP00000062132	Plexin B1.	Rac family small GTPase 1.	0.633
PLXNB1	RHOA	ENSSSCP00000012099	ENSSSCP00000045785	Plexin B1.	Transforming protein RhoA isoform 1.	0.764
PLXNB1	RND1	ENSSSCP00000012099	ENSSSCP00000059270	Plexin B1.	Rho family GTPase 1.	0.982
PLXNB1	RRAS	ENSSSCP00000012099	ENSSSCP00000003452	Plexin B1.	RAS related.	0.960
PLXNB1	SEMA4D	ENSSSCP00000012099	ENSSSCP00000029503	Plexin B1.	Semaphorin-4D isoform X1; Belongs to the semaphorin family.	0.997