(11 nodes) Sema4D induced cell migration and growth-cone collapse network (Sus scrofa)

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Your Input:
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	RHOC	Ras homolog family member C. (202 aa)
	PLXNB1	Plexin B1. (2133 aa)
	SEMA4D	Semaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	RND1	Rho family GTPase 1. (244 aa)
	ROCK2	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1577 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF11	ARHGEF12	ENSSSCP00000068410	ENSSSCP00000047751	Rho guanine nucleotide exchange factor 11.	Rho guanine nucleotide exchange factor 12.	0.927
ARHGEF11	ERBB2	ENSSSCP00000068410	ENSSSCP00000018545	Rho guanine nucleotide exchange factor 11.	Receptor protein-tyrosine kinase.	0.530
ARHGEF11	PLXNB1	ENSSSCP00000068410	ENSSSCP00000012099	Rho guanine nucleotide exchange factor 11.	Plexin B1.	0.737
ARHGEF11	RHOA	ENSSSCP00000068410	ENSSSCP00000045785	Rho guanine nucleotide exchange factor 11.	Transforming protein RhoA isoform 1.	0.970
ARHGEF11	RHOB	ENSSSCP00000068410	ENSSSCP00000069510	Rho guanine nucleotide exchange factor 11.	Rho-related GTP-binding protein RhoB.	0.830
ARHGEF11	RHOC	ENSSSCP00000068410	ENSSSCP00000007228	Rho guanine nucleotide exchange factor 11.	Ras homolog family member C.	0.818
ARHGEF11	RND1	ENSSSCP00000068410	ENSSSCP00000059270	Rho guanine nucleotide exchange factor 11.	Rho family GTPase 1.	0.706
ARHGEF11	ROCK1	ENSSSCP00000068410	ENSSSCP00000063816	Rho guanine nucleotide exchange factor 11.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.629
ARHGEF11	ROCK2	ENSSSCP00000068410	ENSSSCP00000060082	Rho guanine nucleotide exchange factor 11.	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...]	0.602
ARHGEF11	SEMA4D	ENSSSCP00000068410	ENSSSCP00000029503	Rho guanine nucleotide exchange factor 11.	Semaphorin-4D isoform X1; Belongs to the semaphorin family.	0.637
ARHGEF12	ARHGEF11	ENSSSCP00000047751	ENSSSCP00000068410	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 11.	0.927
ARHGEF12	ERBB2	ENSSSCP00000047751	ENSSSCP00000018545	Rho guanine nucleotide exchange factor 12.	Receptor protein-tyrosine kinase.	0.522
ARHGEF12	PLXNB1	ENSSSCP00000047751	ENSSSCP00000012099	Rho guanine nucleotide exchange factor 12.	Plexin B1.	0.944
ARHGEF12	RHOA	ENSSSCP00000047751	ENSSSCP00000045785	Rho guanine nucleotide exchange factor 12.	Transforming protein RhoA isoform 1.	0.968
ARHGEF12	RHOB	ENSSSCP00000047751	ENSSSCP00000069510	Rho guanine nucleotide exchange factor 12.	Rho-related GTP-binding protein RhoB.	0.850
ARHGEF12	RHOC	ENSSSCP00000047751	ENSSSCP00000007228	Rho guanine nucleotide exchange factor 12.	Ras homolog family member C.	0.854
ARHGEF12	RND1	ENSSSCP00000047751	ENSSSCP00000059270	Rho guanine nucleotide exchange factor 12.	Rho family GTPase 1.	0.706
ARHGEF12	ROCK1	ENSSSCP00000047751	ENSSSCP00000063816	Rho guanine nucleotide exchange factor 12.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.558
ARHGEF12	ROCK2	ENSSSCP00000047751	ENSSSCP00000060082	Rho guanine nucleotide exchange factor 12.	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...]	0.575
ARHGEF12	SEMA4D	ENSSSCP00000047751	ENSSSCP00000029503	Rho guanine nucleotide exchange factor 12.	Semaphorin-4D isoform X1; Belongs to the semaphorin family.	0.602