STRINGSTRING
SHC1 SHC1 ITGA5 ITGA5 GNB3 GNB3 PDE8A PDE8A PTH2 PTH2 PDE7B PDE7B GPHB5 GPHB5 CRH CRH PDE7A PDE7A TSHB TSHB AVP AVP MC3R MC3R GNB2 GNB2 GNG13 GNG13 LHCGR LHCGR DRD5 DRD5 ADORA2A ADORA2A GRK5 GRK5 NPS NPS GPR15 GPR15 GPHA2 GPHA2 FSHB FSHB CRSP3 CRSP3 PTH PTH ADM ADM RLN3 RLN3 INSL3 INSL3 GPR150 GPR150 GNGT1 GNGT1 ADRB3 ADRB3 GCG GCG PTH2R PTH2R FN1 FN1 RAMP1 RAMP1 NPSR1 NPSR1 CRHR1 CRHR1 RAMP2 RAMP2 PDE3A PDE3A HRH2 HRH2 ADORA2B ADORA2B HTR6 HTR6 SCTR SCTR P2RY11 P2RY11 GNG2 GNG2 PTGER4 PTGER4 RXFP2 RXFP2 GNG8 GNG8 PDE2A PDE2A GPR20 GPR20 GPER1 GPER1 PTGIR PTGIR PTGER2 PTGER2 GPR32 GPR32 GPR176 GPR176 GNB5 GNB5 GNG3 GNG3 PRKAR2B PRKAR2B ARRB1 ARRB1 GLP2R GLP2R RXFP1 RXFP1 PDE8B PDE8B PDE3B PDE3B GNB4 GNB4 LHB-2 LHB-2 VIPR2 VIPR2 A0A287ACS9_PIG A0A287ACS9_PIG LOC110255211 LOC110255211 GPBAR1 GPBAR1 ADCYAP1R1 ADCYAP1R1 PDE4A PDE4A PDE11A PDE11A GRK6 GRK6 PTHLH PTHLH GPR27 GPR27 CGA CGA PDE4D PDE4D GNB1 GNB1 PDE10A PDE10A PDE4C PDE4C CALCR CALCR PRKAR1B PRKAR1B ARRB2 ARRB2 GPR83 GPR83 PDE1A PDE1A GRK3 GRK3 GIPR GIPR GPR45 GPR45 HTR7 HTR7 PDE1B PDE1B GLP1R GLP1R LOC100621431 LOC100621431 GCGR GCGR GNG10 GNG10 PTH1R PTH1R CRHR2 CRHR2 GRK2 GRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SHC1SHC adaptor protein 1. (583 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
PDE8APhosphodiesterase. (837 aa)
PTH2Parathyroid hormone 2. (98 aa)
PDE7BPhosphodiesterase. (505 aa)
GPHB5Glycoprotein hormone subunit beta 5. (166 aa)
CRHCorticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (191 aa)
PDE7APhosphodiesterase. (483 aa)
TSHBThyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
AVPVasopressin-neurophysin 2-copeptin. (217 aa)
MC3RMelanocortin-3 receptor. (319 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG13G protein subunit gamma 13. (67 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (471 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
NPSNeuropeptide S. (89 aa)
GPR15G protein-coupled receptor 15; Belongs to the G-protein coupled receptor 1 family. (362 aa)
GPHA2Glycoprotein hormone subunit alpha 2. (129 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
CRSP3Calcitonin receptor-stimulating peptide 3; Belongs to the calcitonin family. (125 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
ADMProadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa)
RLN3Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity). (140 aa)
INSL3Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity); Belongs to the insulin family. (131 aa)
GPR150G protein-coupled receptor 150. (431 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
PTH2RParathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (550 aa)
FN1Fibronectin 1. (2462 aa)
RAMP1Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). (271 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (369 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
PDE3APhosphodiesterase. (1145 aa)
HRH2Histamine H2 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (423 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
HTR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
P2RY11PPAN-P2RY11 protein isoform 1; Belongs to the G-protein coupled receptor 1 family. (377 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (248 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
RXFP2Relaxin family peptide receptor 2. (737 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PDE2APhosphodiesterase. (1010 aa)
GPR20G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (352 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GPR32G protein-coupled receptor 32; Belongs to the G-protein coupled receptor 1 family. (345 aa)
GPR176G-protein coupled receptor 176 isoform X1. (515 aa)
GNB5G protein subunit beta 5. (420 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (240 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (468 aa)
ARRB1Arrestin beta 1. (607 aa)
GLP2RGlucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (556 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
PDE8BPhosphodiesterase. (882 aa)
PDE3BPhosphodiesterase. (1117 aa)
GNB4G protein subunit beta 4. (340 aa)
LHB-2Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (173 aa)
VIPR2Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (465 aa)
A0A287ACS9_PIGGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
LOC110255211Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
GPBAR1G protein-coupled bile acid receptor 1. (329 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor short form; Belongs to the G-protein coupled receptor 2 family. (468 aa)
PDE4APhosphodiesterase. (894 aa)
PDE11APhosphodiesterase. (940 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (582 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
GPR27G protein-coupled receptor 27. (376 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (144 aa)
PDE4DPhosphodiesterase. (809 aa)
GNB1G protein subunit beta 1. (395 aa)
PDE10APhosphodiesterase. (788 aa)
PDE4CPhosphodiesterase. (729 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. (490 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (454 aa)
ARRB2Arrestin beta 2. (493 aa)
GPR83G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (415 aa)
PDE1APhosphodiesterase. (545 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (675 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
GPR45G protein-coupled receptor 45. (429 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (475 aa)
PDE1BPhosphodiesterase. (535 aa)
GLP1RUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa)
LOC100621431Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (234 aa)
GCGRG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (482 aa)
GRK2G protein-coupled receptor kinase 2. (778 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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