(17 nodes) Cell-extracellular matrix interactions network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARVB	Parvin beta. (364 aa)
	TESK1	Dual specificity testis-specific protein kinase 1 isoform X1. (629 aa)
	FLNC	Filamin-C isoform X4. (2720 aa)
	ILK	Integrin linked kinase. (479 aa)
	ACTN1	Uncharacterized protein. (888 aa)
	LIMS2	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (357 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	ACTG1	Actin gamma 1. (381 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	VASP	Vasodilator stimulated phosphoprotein. (389 aa)
	FLNA	Filamin A. (2897 aa)
	FBLIM1	Filamin binding LIM protein 1. (415 aa)
	LIMS1	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (397 aa)
	RSU1	Ras suppressor protein 1. (281 aa)
	FERMT2	Fermitin family member 2. (776 aa)
	PXN	Uncharacterized protein. (1072 aa)
	PARVA	Parvin alpha. (373 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSSSCP00000035521	ENSSSCP00000040911	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actin gamma 1.	0.926
ACTB	ACTN1	ENSSSCP00000035521	ENSSSCP00000025103	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.605
ACTB	FLNA	ENSSSCP00000035521	ENSSSCP00000048388	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Filamin A.	0.529
ACTB	ILK	ENSSSCP00000035521	ENSSSCP00000020640	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin linked kinase.	0.496
ACTB	PARVA	ENSSSCP00000035521	ENSSSCP00000064956	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Parvin alpha.	0.911
ACTB	PARVB	ENSSSCP00000035521	ENSSSCP00000000025	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Parvin beta.	0.909
ACTB	PXN	ENSSSCP00000035521	ENSSSCP00000064760	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.961
ACTB	VASP	ENSSSCP00000035521	ENSSSCP00000047185	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Vasodilator stimulated phosphoprotein.	0.955
ACTG1	ACTB	ENSSSCP00000040911	ENSSSCP00000035521	Actin gamma 1.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.926
ACTG1	ACTN1	ENSSSCP00000040911	ENSSSCP00000025103	Actin gamma 1.	Uncharacterized protein.	0.761
ACTG1	FLNA	ENSSSCP00000040911	ENSSSCP00000048388	Actin gamma 1.	Filamin A.	0.664
ACTG1	PARVA	ENSSSCP00000040911	ENSSSCP00000064956	Actin gamma 1.	Parvin alpha.	0.909
ACTG1	PARVB	ENSSSCP00000040911	ENSSSCP00000000025	Actin gamma 1.	Parvin beta.	0.909
ACTG1	PXN	ENSSSCP00000040911	ENSSSCP00000064760	Actin gamma 1.	Uncharacterized protein.	0.922
ACTG1	VASP	ENSSSCP00000040911	ENSSSCP00000047185	Actin gamma 1.	Vasodilator stimulated phosphoprotein.	0.933
ACTN1	ACTB	ENSSSCP00000025103	ENSSSCP00000035521	Uncharacterized protein.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.605
ACTN1	ACTG1	ENSSSCP00000025103	ENSSSCP00000040911	Uncharacterized protein.	Actin gamma 1.	0.761
ACTN1	PARVB	ENSSSCP00000025103	ENSSSCP00000000025	Uncharacterized protein.	Parvin beta.	0.932
ACTN1	PXN	ENSSSCP00000025103	ENSSSCP00000064760	Uncharacterized protein.	Uncharacterized protein.	0.495
ARHGEF6	PARVB	ENSSSCP00000043202	ENSSSCP00000000025	Rac/Cdc42 guanine nucleotide exchange factor 6.	Parvin beta.	0.925