STRINGSTRING
RPS6KA5 RPS6KA5 MAPK10 MAPK10 DUSP4 DUSP4 MAPK11 MAPK11 RPS6KA2 RPS6KA2 CREB1 CREB1 RPS6KA1 RPS6KA1 DUSP6 DUSP6 MAPK7 MAPK7 ATF2 ATF2 PPP2R5D PPP2R5D MAPK3 MAPK3 MAPK9 MAPK9 MAPK14 MAPK14 RPS6KA3 RPS6KA3 PPP2CB PPP2CB MAPK1 MAPK1 DUSP3 DUSP3 VRK3 VRK3 MAPK8 MAPK8 PPP2CA PPP2CA MAPKAPK2 MAPKAPK2 ATF1 ATF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KA5Non-specific serine/threonine protein kinase. (957 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (436 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RPS6KA2Ribosomal protein S6 kinase. (759 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
RPS6KA1Ribosomal protein S6 kinase. (856 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (840 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (614 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
MAPK9Mitogen-activated protein kinase 9. (461 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA3Ribosomal protein S6 kinase. (744 aa)
PPP2CBSerine/threonine-protein phosphatase. (476 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
VRK3VRK serine/threonine kinase 3. (513 aa)
MAPK8Mitogen-activated protein kinase. (411 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
ATF1Activating transcription factor 1. (269 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.