(29 nodes) Interleukin-2 family signaling network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	GAB2	GRB2 associated binding protein 2. (740 aa)
	CSF2RB	Colony stimulating factor 2 receptor beta common subunit. (893 aa)
	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	IL21R	Interleukin 21 receptor. (547 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	IL5RA	Interleukin 5 receptor subunit alpha. (420 aa)
	IL2RG	Cytokine receptor common subunit gamma. (395 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	STAT3	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
	IL9	Uncharacterized protein. (141 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (783 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	IL15RA	Sushi domain-containing protein. (305 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	JAK2	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
	JAK3	Tyrosine-protein kinase. (1103 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC100511937	Uncharacterized protein. (532 aa)
	CSF2RA	Fibronectin type-III domain-containing protein. (446 aa)
	PIK3R2	Uncharacterized protein. (772 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF2	CSF2RA	ENSSSCP00000020413	ENSSSCP00000054835	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Fibronectin type-III domain-containing protein.	0.991
CSF2	CSF2RB	ENSSSCP00000020413	ENSSSCP00000000140	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Colony stimulating factor 2 receptor beta common subunit.	0.984
CSF2	GAB2	ENSSSCP00000020413	ENSSSCP00000051969	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	GRB2 associated binding protein 2.	0.400
CSF2	GRB2	ENSSSCP00000020413	ENSSSCP00000018229	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Growth factor receptor-bound protein 2 isoform 1.	0.419
CSF2	IL15RA	ENSSSCP00000020413	ENSSSCP00000025149	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Sushi domain-containing protein.	0.679
CSF2	IL21R	ENSSSCP00000020413	ENSSSCP00000008345	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Interleukin 21 receptor.	0.688
CSF2	IL2RB	ENSSSCP00000020413	ENSSSCP00000022046	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Fibronectin type-III domain-containing protein.	0.650
CSF2	IL2RG	ENSSSCP00000020413	ENSSSCP00000013192	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Cytokine receptor common subunit gamma.	0.666
CSF2	IL5RA	ENSSSCP00000020413	ENSSSCP00000012287	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Interleukin 5 receptor subunit alpha.	0.782
CSF2	IL9	ENSSSCP00000020413	ENSSSCP00000019202	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Uncharacterized protein.	0.827
CSF2	INPP5D	ENSSSCP00000020413	ENSSSCP00000041449	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1.	0.505
CSF2	JAK1	ENSSSCP00000020413	ENSSSCP00000032415	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Tyrosine-protein kinase.	0.647
CSF2	JAK2	ENSSSCP00000020413	ENSSSCP00000029236	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.727
CSF2	JAK3	ENSSSCP00000020413	ENSSSCP00000030830	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Tyrosine-protein kinase.	0.571
CSF2	LOC100511937	ENSSSCP00000020413	ENSSSCP00000053353	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Uncharacterized protein.	0.400
CSF2	PIK3CA	ENSSSCP00000020413	ENSSSCP00000052984	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.425
CSF2	PIK3CB	ENSSSCP00000020413	ENSSSCP00000052823	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.400
CSF2	PIK3CD	ENSSSCP00000020413	ENSSSCP00000003679	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.413
CSF2	PIK3R1	ENSSSCP00000020413	ENSSSCP00000024885	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Phosphoinositide-3-kinase regulatory subunit 1.	0.400
CSF2	PIK3R2	ENSSSCP00000020413	ENSSSCP00000060475	Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	Uncharacterized protein.	0.400