STRINGSTRING
SMURF1 SMURF1 PSMB9 PSMB9 PSME1 PSME1 PSMB11 PSMB11 PSMC1 PSMC1 PSMA8 PSMA8 PSMB7 PSMB7 PSMD4 PSMD4 PSMA5 PSMA5 PSMD6 PSMD6 KXD1 KXD1 PSMC2 PSMC2 FZD7 FZD7 FZD5 FZD5 PSMD1 PSMD1 PSMD3 PSMD3 PSMD11 PSMD11 DVL2 DVL2 PSME3 PSME3 PSMF1 PSMF1 PSMD9 PSMD9 PSMB3 PSMB3 A0A286ZS34_PIG A0A286ZS34_PIG FZD3 FZD3 PSMD12 PSMD12 WNT5A WNT5A PSMD7 PSMD7 FZD2 FZD2 FZD1 FZD1 PRICKLE1 PRICKLE1 PSME4 PSME4 SMURF2 SMURF2 RPS27A RPS27A PSMC4 PSMC4 PSMD8 PSMD8 FZD8 FZD8 PSMC6 PSMC6 PSMD14 PSMD14 PSMB1 PSMB1 PSMB10 PSMB10 PSMA7 PSMA7 PSMD10 PSMD10 FZD4 FZD4 PSMA1 PSMA1 PSMD5 PSMD5 UBC UBC PSMA2 PSMA2 PSMC5 PSMC5 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 PSMD13 PSMD13 PARD6A PARD6A PSMC3 PSMC3 PSMB6 PSMB6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (859 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMB11Proteasome subunit beta. (291 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
DVL2Dishevelled segment polarity protein 2. (794 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
PSMF1Uncharacterized protein. (351 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMB3Proteasome subunit beta. (205 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
PARD6APar-6 family cell polarity regulator alpha. (354 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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