(20 nodes) Regulation of FZD by ubiquitination network (Sus scrofa)

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Your Input:
	RPS27A	Ubiquitin-like domain-containing protein. (204 aa)
	FZD6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
	RSPO4	R-spondin 4. (235 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
	KXD1	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	RSPO3	Uncharacterized protein. (280 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1115 aa)
	LRTM1	Leucine-rich repeat and transmembrane domain-containing protein 1 isoform 1. (345 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
	RSPO1	R-spondin 1. (262 aa)
	RNF43	RING-type domain-containing protein. (743 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
	UBC	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
	ZNRF3	Zinc and ring finger 3. (912 aa)
	RSPO2	Uncharacterized protein. (242 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD4	FZD5	ENSSSCP00000059855	ENSSSCP00000017100	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.534
FZD4	FZD6	ENSSSCP00000059855	ENSSSCP00000006462	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.596
FZD4	FZD8	ENSSSCP00000059855	ENSSSCP00000054698	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.527
FZD4	KXD1	ENSSSCP00000059855	ENSSSCP00000014786	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.499
FZD4	LGR4	ENSSSCP00000059855	ENSSSCP00000014168	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1.	0.619
FZD4	LRP5	ENSSSCP00000059855	ENSSSCP00000013700	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.983
FZD4	LRP6	ENSSSCP00000059855	ENSSSCP00000040912	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.980
FZD4	RNF43	ENSSSCP00000059855	ENSSSCP00000051795	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	RING-type domain-containing protein.	0.645
FZD4	RPS27A	ENSSSCP00000059855	ENSSSCP00000049299	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-like domain-containing protein.	0.540
FZD4	UBC	ENSSSCP00000059855	ENSSSCP00000062692	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...]	0.552
FZD4	USP8	ENSSSCP00000059855	ENSSSCP00000034958	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.459
FZD4	WNT3A	ENSSSCP00000059855	ENSSSCP00000021525	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.934
FZD4	ZNRF3	ENSSSCP00000059855	ENSSSCP00000063657	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Zinc and ring finger 3.	0.931
FZD5	FZD4	ENSSSCP00000017100	ENSSSCP00000059855	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.534
FZD5	FZD6	ENSSSCP00000017100	ENSSSCP00000006462	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.679
FZD5	FZD8	ENSSSCP00000017100	ENSSSCP00000054698	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.607
FZD5	KXD1	ENSSSCP00000017100	ENSSSCP00000014786	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.499
FZD5	LRP5	ENSSSCP00000017100	ENSSSCP00000013700	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.963
FZD5	LRP6	ENSSSCP00000017100	ENSSSCP00000040912	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.961
FZD5	RNF43	ENSSSCP00000017100	ENSSSCP00000051795	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	RING-type domain-containing protein.	0.768