STRINGSTRING
PDPK1 PDPK1 LOC100152135 LOC100152135 LOC100152878 LOC100152878 KDM1A KDM1A PKN3 PKN3 YWHAZ YWHAZ H2AC20 H2AC20 LOC102159655 LOC102159655 RHOC RHOC H2AFZ H2AFZ LOC100155267 LOC100155267 YWHAH YWHAH CDC25C CDC25C LOC100521680 LOC100521680 I3LAJ9_PIG I3LAJ9_PIG HIST1H2BD HIST1H2BD LOC100158121 LOC100158121 LOC100621389 LOC100621389 PKN2 PKN2 A0A286ZRB3_PIG A0A286ZRB3_PIG PPP1R14A PPP1R14A H2BC11 H2BC11 KDM4C KDM4C NCOA2 NCOA2 H2AJ H2AJ RHOA RHOA H2BU1 H2BU1 PKN1 PKN1 PPP1CB PPP1CB PPP1R12B PPP1R12B H2AC6 H2AC6 HIST1H3E HIST1H3E LOC100620620 LOC100620620 H2BC21 H2BC21 YWHAB YWHAB YWHAG YWHAG H2AX H2AX RAC1 RAC1 YWHAQ YWHAQ PPP1R12A PPP1R12A RHOB RHOB H2AZ2 H2AZ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
LOC100152135Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC100152878Histone H2B; Belongs to the histone H2B family. (127 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
PKN3Protein kinase N3. (861 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC102159655Histone H2A; Belongs to the histone H2A family. (130 aa)
RHOCRas homolog family member C. (202 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
LOC100155267Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
I3LAJ9_PIGHistone H2B; Belongs to the histone H2B family. (168 aa)
HIST1H2BDHistone H2B; Belongs to the histone H2B family. (126 aa)
LOC100158121Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC100621389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PKN2Serine/threonine-protein kinase N2 isoform 1. (983 aa)
A0A286ZRB3_PIGHistone domain-containing protein. (130 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. (147 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (149 aa)
KDM4CLysine demethylase 4C. (1056 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
PKN1Protein kinase N1. (956 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1012 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (145 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
LOC100620620Histone H2A; Belongs to the histone H2A family. (113 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
RAC1Rac family small GTPase 1. (186 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (246 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1028 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (145 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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