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RHEB RHEB SLC38A9 SLC38A9 COX19 COX19 COX7C COX7C TACO1 TACO1 LAMTOR3 LAMTOR3 A0A287AZF5_PIG A0A287AZF5_PIG LAMTOR5 LAMTOR5 A0A287BCA6_PIG A0A287BCA6_PIG TSC2 TSC2 COX6A1 COX6A1 GLS GLS PRKAA2 PRKAA2 COX7B COX7B YWHAB YWHAB YWHAG YWHAG G6PD G6PD COX7A2L COX7A2L SCO2 SCO2 SESN2 SESN2 SESN1 SESN1 YWHAQ YWHAQ COX4I1 COX4I1 LAMTOR4 LAMTOR4 TSC1 TSC1 LAMTOR1 LAMTOR1 PRKAG1 PRKAG1 GLS2 GLS2 GPX2 GPX2 COX16 COX16 GPI GPI MTOR MTOR RRAGC RRAGC RRAGA RRAGA YWHAZ YWHAZ LAMTOR2 LAMTOR2 PRKAB2 PRKAB2 MLST8 MLST8 COX5B COX5B LRPPRC LRPPRC COX18 COX18 YWHAH YWHAH PRDX5 PRDX5 COX8A COX8A GSR GSR PRKAG2 PRKAG2 CYCS CYCS COX11 COX11 F1RHI4_PIG F1RHI4_PIG COX1 COX1 COX3 COX3 COX5A COX5A RPTOR RPTOR TIGAR TIGAR I3LCB9_PIG I3LCB9_PIG NDUFA4 NDUFA4 RRAGB RRAGB LOC100519295 LOC100519295 RRAGD RRAGD PRDX1 PRDX1 A0A286ZQJ2_PIG A0A286ZQJ2_PIG SURF1 SURF1 SESN3 SESN3 COX20 COX20 COX6B COX6B DDIT4 DDIT4 SCO1 SCO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHEBUncharacterized protein. (220 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9 isoform X2. (531 aa)
COX19Cytochrome c oxidase assembly factor COX19. (89 aa)
COX7CCytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (63 aa)
TACO1Uncharacterized protein. (321 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
A0A287AZF5_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMTOR5Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa)
A0A287BCA6_PIGThioredoxin domain-containing protein. (99 aa)
TSC2TSC complex subunit 2. (1836 aa)
COX6A1Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa)
GLSGlutaminase. (669 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
COX7BCytochrome c oxidase subunit 7B, mitochondrial. (80 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (649 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (140 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (264 aa)
SESN2Sestrin 2. (471 aa)
SESN1Sestrin 1. (582 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (246 aa)
COX4I1Cytochrome c oxidase subunit 4 isoform 1, mitochondrial. (203 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (100 aa)
TSC1TSC complex subunit 1. (1166 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
GLS2Glutaminase 2. (602 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
COX16Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1. (106 aa)
GPIGlucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (558 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
RRAGCRas related GTP binding C. (440 aa)
RRAGARas related GTP binding A. (313 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa)
LAMTOR2Ragulator complex protein LAMTOR2 isoform 1. (125 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
MLST8MTOR associated protein, LST8 homolog. (455 aa)
COX5BCytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (129 aa)
LRPPRCLeucine-rich PPR motif-containing protein, mitochondrial. (1394 aa)
COX18Cytochrome c oxidase assembly factor COX18. (337 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (170 aa)
COX8ACytochrome c oxidase subunit 8A, mitochondrial. (69 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (271 aa)
F1RHI4_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
COX5ACytochrome c oxidase subunit 5A, mitochondrial. (152 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1351 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
I3LCB9_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NDUFA4Cytochrome c oxidase subunit NDUFA4. (137 aa)
RRAGBRas-related GTP-binding protein B long isoform. (374 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
PRDX1Peroxiredoxin-1. (224 aa)
A0A286ZQJ2_PIGCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
SURF1SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. (300 aa)
SESN3Sestrin-3 isoform 1. (492 aa)
COX20Cytochrome c oxidase assembly factor COX20. (119 aa)
COX6BCytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
DDIT4Uncharacterized protein. (231 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (305 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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