STRINGSTRING
PSMD7 PSMD7 DHH DHH PSMB9 PSMB9 KIF7 KIF7 PSME1 PSME1 PSMB11 PSMB11 PSMC1 PSMC1 PSMA8 PSMA8 PSMB7 PSMB7 GPR161 GPR161 PSMD4 PSMD4 PSMA5 PSMA5 SUFU SUFU CDC73 CDC73 PSMD6 PSMD6 KXD1 KXD1 PSMC2 PSMC2 GLI2 GLI2 IHH IHH PSMD1 PSMD1 SHH SHH SMO SMO GLI3 GLI3 PSMD3 PSMD3 PSMD11 PSMD11 EVC2 EVC2 SPOP SPOP PSMF1 PSMF1 CDON CDON PTCH1 PTCH1 PSMD9 PSMD9 PSMB3 PSMB3 A0A286ZS34_PIG A0A286ZS34_PIG PSMD12 PSMD12 CUL3 CUL3 NUMB NUMB ITCH ITCH IQCE IQCE PSME4 PSME4 EFCAB7 EFCAB7 SPOPL SPOPL SMURF2 SMURF2 RPS27A RPS27A EVC EVC PSMC4 PSMC4 RBX1 RBX1 PSMD8 PSMD8 HHIP HHIP PSMC6 PSMC6 GLI1 GLI1 PSMD14 PSMD14 PSMB1 PSMB1 PSMB10 PSMB10 PSMA7 PSMA7 PSMD10 PSMD10 PSMA1 PSMA1 PSMD5 PSMD5 UBC UBC PSMA2 PSMA2 PSMC5 PSMC5 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 PSMD13 PSMD13 PSMC3 PSMC3 PSMB6 PSMB6 SMURF1 SMURF1 PSME3 PSME3 GRK2 GRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
PSMB9Proteasome subunit beta. (219 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1356 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMB11Proteasome subunit beta. (291 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
SUFUSUFU negative regulator of hedgehog signaling. (432 aa)
CDC73Cell division cycle 73. (531 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
GLI2GLI family zinc finger 2. (1551 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
GLI3GLI family zinc finger 3. (1586 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
EVC2EvC ciliary complex subunit 2. (1299 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
PSMF1Uncharacterized protein. (351 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMB3Proteasome subunit beta. (205 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
CUL3Cullin 3; Belongs to the cullin family. (773 aa)
NUMBNUMB endocytic adaptor protein. (653 aa)
ITCHE3 ubiquitin-protein ligase. (873 aa)
IQCEIQ motif containing E. (716 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
EFCAB7EF-hand calcium binding domain 7. (662 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
EVCEllis-van Creveld syndrome protein isoform 2. (991 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
HHIPHedgehog-interacting protein. (700 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
SMURF1E3 ubiquitin-protein ligase. (859 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
GRK2G protein-coupled receptor kinase 2. (778 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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