(19 nodes) SHC-mediated cascade:FGFR4 network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	KLB	Klotho beta. (1044 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	FGFR4	Fibroblast growth factor receptor. (903 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
	FGF9	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF16	FGF17	ENSSSCP00000020630	ENSSSCP00000010256	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.468
FGF16	FGF18	ENSSSCP00000020630	ENSSSCP00000028172	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
FGF16	FGF19	ENSSSCP00000020630	ENSSSCP00000051161	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.675
FGF16	FGF2	ENSSSCP00000020630	ENSSSCP00000055271	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.622
FGF16	FGF20	ENSSSCP00000020630	ENSSSCP00000007438	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.414
FGF16	FGF23	ENSSSCP00000020630	ENSSSCP00000048736	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.742
FGF16	FGF4	ENSSSCP00000020630	ENSSSCP00000013681	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.511
FGF16	FGF6	ENSSSCP00000020630	ENSSSCP00000042869	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.583
FGF16	FGF8	ENSSSCP00000020630	ENSSSCP00000066541	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
FGF16	FGF9	ENSSSCP00000020630	ENSSSCP00000060438	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	0.420
FGF16	FGFR4	ENSSSCP00000020630	ENSSSCP00000030615	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.922
FGF16	GRB2	ENSSSCP00000020630	ENSSSCP00000018229	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2 isoform 1.	0.602
FGF16	HRAS	ENSSSCP00000020630	ENSSSCP00000051149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	HRas proto-oncogene, GTPase.	0.543
FGF16	KLB	ENSSSCP00000020630	ENSSSCP00000019159	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Klotho beta.	0.619
FGF16	KRAS	ENSSSCP00000020630	ENSSSCP00000021836	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	KRAS proto-oncogene, GTPase.	0.588
FGF16	NRAS	ENSSSCP00000020630	ENSSSCP00000046185	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.534
FGF16	SHC1	ENSSSCP00000020630	ENSSSCP00000028571	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SHC adaptor protein 1.	0.445
FGF16	SOS1	ENSSSCP00000020630	ENSSSCP00000009045	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.457
FGF17	FGF16	ENSSSCP00000010256	ENSSSCP00000020630	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.468
FGF17	FGF18	ENSSSCP00000010256	ENSSSCP00000028172	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429