STRINGSTRING
BRAF BRAF FRS3 FRS3 FGF20 FGF20 PLCG1 PLCG1 SPRED2 SPRED2 SOS1 SOS1 KL KL FGF17 FGF17 FGF4 FGF4 FGF3 FGF3 FLRT1 FLRT1 KXD1 KXD1 PPP2CA PPP2CA FGF10 FGF10 GRB2 GRB2 KRAS KRAS PIK3R1 PIK3R1 FGF18 FGF18 SHC1 SHC1 GAB1 GAB1 SRC SRC FLRT3 FLRT3 FGFR1 FGFR1 ANOS1-2 ANOS1-2 A0A286ZJU7_PIG A0A286ZJU7_PIG CBL CBL FGF5 FGF5 MKNK1 MKNK1 FGF6 FGF6 FGFRL1 FGFRL1 NRAS NRAS FGF23 FGF23 RPS27A RPS27A FLRT2 FLRT2 HRAS HRAS PIK3CA PIK3CA FRS2 FRS2 FGF2 FGF2 FGF22 FGF22 MAPK3 MAPK3 FGF9 FGF9 UBC UBC PTPN11 PTPN11 FGF8 FGF8 SPRED1 SPRED1 SPRY2 SPRY2 PPP2CB PPP2CB MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2 isoform a. (417 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
KLKlotho. (1011 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
FLRT1Leucine-rich repeat transmembrane protein FLRT1 isoform X1. (674 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
SHC1SHC adaptor protein 1. (583 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
SRCTyrosine-protein kinase. (559 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ANOS1-2Uncharacterized protein. (620 aa)
A0A286ZJU7_PIGUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (235 aa)
CBLCbl proto-oncogene. (914 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (471 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFRL1Fibroblast growth factor receptor like 1. (566 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2 isoform X1. (660 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SPRED1Sprouty related EVH1 domain containing 1. (445 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
PPP2CBSerine/threonine-protein phosphatase. (476 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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