30 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA3	Replication protein A3. (121 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (805 aa)
	POLE3	Uncharacterized protein. (171 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	KXD1	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
	POLK	DNA polymerase kappa. (870 aa)
	USP43	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1104 aa)
	POLD3	Uncharacterized protein. (463 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	UBE2L6	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	RFC1	Replication factor C subunit 1. (1141 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (471 aa)
	POLI	DNA polymerase iota isoform a (Long). (750 aa)
	RFC5	Replication factor C subunit 5. (343 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
	REV1	REV1 DNA directed polymerase. (1350 aa)
	POLH	DNA polymerase eta. (698 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (204 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
	POLD1	DNA polymerase. (1152 aa)
	RFC2	Replication factor C subunit 2 isoform 1. (352 aa)
	POLD4	Uncharacterized protein. (134 aa)
	UBC	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
	RFC3	Replication factor C subunit 3 isoform 1. (356 aa)
	TRIM25	Tripartite motif containing 25. (633 aa)
	PCLAF	PAF domain-containing protein. (112 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (138 aa)
	RPA2	RPA_C domain-containing protein. (270 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ISG15	KXD1	ENSSSCP00000041015	ENSSSCP00000014786	Ubiquitin-like modifier.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.551
ISG15	PCLAF	ENSSSCP00000041015	ENSSSCP00000070433	Ubiquitin-like modifier.	PAF domain-containing protein.	0.499
ISG15	PCNA	ENSSSCP00000041015	ENSSSCP00000041307	Ubiquitin-like modifier.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.940
ISG15	POLD1	ENSSSCP00000041015	ENSSSCP00000052525	Ubiquitin-like modifier.	DNA polymerase.	0.499
ISG15	POLD2	ENSSSCP00000041015	ENSSSCP00000031838	Ubiquitin-like modifier.	DNA polymerase delta 2, accessory subunit.	0.499
ISG15	POLD3	ENSSSCP00000041015	ENSSSCP00000019258	Ubiquitin-like modifier.	Uncharacterized protein.	0.534
ISG15	POLD4	ENSSSCP00000041015	ENSSSCP00000060517	Ubiquitin-like modifier.	Uncharacterized protein.	0.503
ISG15	POLE	ENSSSCP00000041015	ENSSSCP00000051522	Ubiquitin-like modifier.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.602
ISG15	POLE3	ENSSSCP00000041015	ENSSSCP00000005874	Ubiquitin-like modifier.	Uncharacterized protein.	0.510
ISG15	POLE4	ENSSSCP00000041015	ENSSSCP00000072737	Ubiquitin-like modifier.	DNA polymerase epsilon 4, accessory subunit.	0.522
ISG15	POLH	ENSSSCP00000041015	ENSSSCP00000045974	Ubiquitin-like modifier.	DNA polymerase eta.	0.645
ISG15	POLI	ENSSSCP00000041015	ENSSSCP00000034918	Ubiquitin-like modifier.	DNA polymerase iota isoform a (Long).	0.706
ISG15	POLK	ENSSSCP00000041015	ENSSSCP00000014975	Ubiquitin-like modifier.	DNA polymerase kappa.	0.592
ISG15	REV1	ENSSSCP00000041015	ENSSSCP00000041774	Ubiquitin-like modifier.	REV1 DNA directed polymerase.	0.674
ISG15	RFC1	ENSSSCP00000041015	ENSSSCP00000031796	Ubiquitin-like modifier.	Replication factor C subunit 1.	0.512
ISG15	RFC2	ENSSSCP00000041015	ENSSSCP00000059225	Ubiquitin-like modifier.	Replication factor C subunit 2 isoform 1.	0.575
ISG15	RFC3	ENSSSCP00000041015	ENSSSCP00000066886	Ubiquitin-like modifier.	Replication factor C subunit 3 isoform 1.	0.520
ISG15	RFC4	ENSSSCP00000041015	ENSSSCP00000012575	Ubiquitin-like modifier.	Replication factor C subunit 4.	0.518
ISG15	RFC5	ENSSSCP00000041015	ENSSSCP00000039406	Ubiquitin-like modifier.	Replication factor C subunit 5.	0.518
ISG15	RPA1	ENSSSCP00000041015	ENSSSCP00000023457	Ubiquitin-like modifier.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.504