STRINGSTRING
PSMD13 PSMD13 CD27 CD27 PSMB9 PSMB9 PSME1 PSME1 PSMB11 PSMB11 PSMC1 PSMC1 TNFRSF25 TNFRSF25 PSMA8 PSMA8 PSMB7 PSMB7 TRAF2 TRAF2 PSMD4 PSMD4 PSMA5 PSMA5 EDAR EDAR TNFSF11 TNFSF11 TNFSF13B TNFSF13B CHUK CHUK NFKB2 NFKB2 PSMD6 PSMD6 KXD1 KXD1 PSMC2 PSMC2 TNFSF18 TNFSF18 PSMD1 PSMD1 MAP3K14 MAP3K14 PSMD3 PSMD3 PSMD11 PSMD11 TNFRSF12A TNFRSF12A TNFSF9 TNFSF9 PSMF1 PSMF1 LTA LTA TNFRSF11A TNFRSF11A EDA EDA TNFRSF9 TNFRSF9 PSMD9 PSMD9 PSMB3 PSMB3 TNFRSF13B TNFRSF13B TNFSF13 TNFSF13 RELB RELB A0A286ZS34_PIG A0A286ZS34_PIG EDARADD EDARADD PSMD12 PSMD12 TNFRSF18 TNFRSF18 TNFRSF4 TNFRSF4 PSMD7 PSMD7 TRAF3 TRAF3 TNFRSF13C TNFRSF13C PSME4 PSME4 TNFSF15 TNFSF15 TNFSF12 TNFSF12 RPS27A RPS27A BIRC3 BIRC3 PSMC4 PSMC4 PSMD8 PSMD8 CD40 CD40 PSMC6 PSMC6 PSMD14 PSMD14 TNFRSF17 TNFRSF17 PSMB1 PSMB1 PSMB10 PSMB10 PSMA7 PSMA7 PSMD10 PSMD10 LTBR LTBR PSMA1 PSMA1 PSMD5 PSMD5 TNF TNF UBC UBC PSMA2 PSMA2 TNFRSF1B TNFRSF1B PSMC5 PSMC5 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 TNFSF14 TNFSF14 PSMC3 PSMC3 PSMB6 PSMB6 PSME3 PSME3 TNFSF4 TNFSF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
CD27CD27. (249 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMB11Proteasome subunit beta. (291 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
TNFRSF25TNF receptor superfamily member 25. (378 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
EDAREctodysplasin A receptor. (461 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (233 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (901 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
TNFSF18TNF superfamily member 18. (178 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (930 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
TNFRSF12AUncharacterized protein. (94 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (259 aa)
PSMF1Uncharacterized protein. (351 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (204 aa)
TNFRSF11ATNF receptor superfamily member 11a. (629 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (389 aa)
TNFRSF9TNF receptor superfamily member 9. (260 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMB3Proteasome subunit beta. (205 aa)
TNFRSF13BTACI-CRD2 domain-containing protein. (247 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
EDARADDEDAR associated death domain. (207 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
TNFRSF18TNFR-Cys domain-containing protein. (331 aa)
TNFRSF4TNF receptor superfamily member 4. (278 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C. (186 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
TNFSF15TNF_2 domain-containing protein. (250 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (386 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
TNFRSF17TNF receptor superfamily member 17. (178 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LTBRUncharacterized protein. (432 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4 isoform X1; Belongs to the tumor necrosis factor family. (182 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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