(33 nodes) MAP2K and MAPK activation network (Sus scrofa)

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Your Input:
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	CSK	Tyrosine-protein kinase. (474 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2 isoform 1. (125 aa)
	PEBP1	Uncharacterized protein. (187 aa)
	KSR2	Kinase suppressor of ras 2. (950 aa)
	VCL	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
	IL17RD	Interleukin-17 receptor D isoform a. (737 aa)
	WDR83	WD repeat domain-containing protein 83. (311 aa)
	FN1	Fibronectin 1. (2462 aa)
	KSR1	Kinase suppressor of ras 1. (928 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (835 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	FGG	Fibrinogen gamma chain. (454 aa)
	CNKSR1	Connector enhancer of kinase suppressor of Ras 1. (648 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	ARRB1	Arrestin beta 1. (607 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (804 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein. (688 aa)
	MARK3	Non-specific serine/threonine protein kinase. (798 aa)
	ACTG1	Actin gamma 1. (381 aa)
	TLN1	Talin 1. (2558 aa)
	CNKSR2	Connector enhancer of kinase suppressor of Ras 2. (1050 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
	ARRB2	Arrestin beta 2. (493 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	LAMTOR3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSSSCP00000035521	ENSSSCP00000040911	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actin gamma 1.	0.926
ACTB	ARRB1	ENSSSCP00000035521	ENSSSCP00000033134	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Arrestin beta 1.	0.513
ACTB	ARRB2	ENSSSCP00000035521	ENSSSCP00000060730	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Arrestin beta 2.	0.512
ACTB	BRAF	ENSSSCP00000035521	ENSSSCP00000035615	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	B-Raf proto-oncogene, serine/threonine kinase.	0.607
ACTB	HRAS	ENSSSCP00000035521	ENSSSCP00000051149	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	HRas proto-oncogene, GTPase.	0.573
ACTB	IQGAP1	ENSSSCP00000035521	ENSSSCP00000001984	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	IQ motif containing GTPase activating protein 1.	0.945
ACTB	ITGB3	ENSSSCP00000035521	ENSSSCP00000072331	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin beta; Belongs to the integrin beta chain family.	0.955
ACTB	KRAS	ENSSSCP00000035521	ENSSSCP00000021836	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	KRAS proto-oncogene, GTPase.	0.641
ACTB	MAPK1	ENSSSCP00000035521	ENSSSCP00000073842	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.609
ACTB	NRAS	ENSSSCP00000035521	ENSSSCP00000046185	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.595
ACTB	SRC	ENSSSCP00000035521	ENSSSCP00000029882	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase.	0.717
ACTB	TLN1	ENSSSCP00000035521	ENSSSCP00000041366	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Talin 1.	0.451
ACTB	VCL	ENSSSCP00000035521	ENSSSCP00000010997	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.754
ACTB	YWHAB	ENSSSCP00000035521	ENSSSCP00000058156	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.646
ACTG1	ACTB	ENSSSCP00000040911	ENSSSCP00000035521	Actin gamma 1.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.926
ACTG1	IQGAP1	ENSSSCP00000040911	ENSSSCP00000001984	Actin gamma 1.	IQ motif containing GTPase activating protein 1.	0.930
ACTG1	ITGB3	ENSSSCP00000040911	ENSSSCP00000072331	Actin gamma 1.	Integrin beta; Belongs to the integrin beta chain family.	0.920
ACTG1	SRC	ENSSSCP00000040911	ENSSSCP00000029882	Actin gamma 1.	Tyrosine-protein kinase.	0.418
ACTG1	TLN1	ENSSSCP00000040911	ENSSSCP00000041366	Actin gamma 1.	Talin 1.	0.538
ACTG1	VCL	ENSSSCP00000040911	ENSSSCP00000010997	Actin gamma 1.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.777