STRINGSTRING
ABL1 ABL1 TOP3A TOP3A MRE11 MRE11 TIPIN TIPIN RAD50 RAD50 RAD17 RAD17 RFC2 RFC2 TOPBP1 TOPBP1 PPP4C PPP4C POLD4 POLD4 UBC UBC ATRIP ATRIP KAT5 KAT5 RFC3 RFC3 BARD1 BARD1 EXO1 EXO1 POLE4 POLE4 RAD51B RAD51B RPA2 RPA2 CDK2 CDK2 TIMELESS TIMELESS BLM BLM XRCC3 XRCC3 RAD51 RAD51 POLE3 POLE3 SLX4 SLX4 CCNA1 CCNA1 RAD9B RAD9B RMI1 RMI1 ATR ATR RFC4 RFC4 RAD9A RAD9A MUS81 MUS81 SIRT6 SIRT6 KXD1 KXD1 POLK POLK CHEK1 CHEK1 WRN WRN RAD1 RAD1 EME1 EME1 POLD3 POLD3 RMI2 RMI2 EME2 EME2 RPA3 RPA3 RPA1 RPA1 RAD51C RAD51C RFC1 RFC1 POLD2 POLD2 RBBP8 RBBP8 CLSPN CLSPN RAD51AP1 RAD51AP1 BRCA1 BRCA1 SLX1A SLX1A PALB2 PALB2 RFC5 RFC5 HUS1 HUS1 PCNA PCNA GEN1 GEN1 RAD52 RAD52 POLH POLH BRIP1 BRIP1 DNA2 DNA2 NBN NBN SPIDR SPIDR RPS27A RPS27A PPP4R2 PPP4R2 XRCC2 XRCC2 POLE POLE POLD1 POLD1 RHNO1 RHNO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1146 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (320 aa)
RAD50Zinc-hook domain-containing protein. (1358 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (711 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1583 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
POLD4Uncharacterized protein. (134 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
ATRIPATR interacting protein. (823 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EXO1Exonuclease 1. (836 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (138 aa)
RAD51BRAD51 paralog B. (365 aa)
RPA2RPA_C domain-containing protein. (270 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
BLMBLM RecQ like helicase. (1432 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (357 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
POLE3Uncharacterized protein. (171 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1778 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (398 aa)
RMI1RecQ mediated genome instability 1. (623 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
RFC4Replication factor C subunit 4. (364 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa)
MUS81MUS81 structure-specific endonuclease subunit. (631 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (327 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
POLKDNA polymerase kappa. (870 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
WRNWRN RecQ like helicase. (1466 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
EME1Essential meiotic structure-specific endonuclease 1. (576 aa)
POLD3Uncharacterized protein. (463 aa)
RMI2RecQ-mediated genome instability protein 2. (150 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (373 aa)
RPA3Replication protein A3. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RAD51CRAD51 paralog C. (371 aa)
RFC1Replication factor C subunit 1. (1141 aa)
POLD2DNA polymerase delta 2, accessory subunit. (471 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
CLSPNClaspin. (1325 aa)
RAD51AP1RAD51 associated protein 1. (345 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
PALB2Partner and localizer of BRCA2. (1189 aa)
RFC5Replication factor C subunit 5. (343 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (289 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
RAD52RAD52 homolog, DNA repair protein. (406 aa)
POLHDNA polymerase eta. (698 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (978 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
SPIDRDNA repair-scaffolding protein isoform 1. (924 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (414 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1152 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.